The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8+ T cells in mice

The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8+ T cells in mice

ABSTRACT The gut microbiota is closely associated with inflammatory bowel disease (IBD) and colorectal cancer (CRC). Probiotics such as Clostridium butyricum (CB) or Akkermansia muciniphila (AKK) have the potential to treat inflammatory bowel disease (IBD) or colorectal cancer (CRC). However, resear...

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Main Authors: Dengxiong Hua, Qin Yang, Xiaowei Li, Xuexue Zhou, Yingqian Kang, Yan Zhao, Daoyan Wu, Zhengrong Zhang, Boyan Li, Xinxin Wang, Xiaolan Qi, Zhenghong Chen, Guzhen Cui, Wei Hong
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mSystems
Subjects:
probiotic bacteria
Clostridium butyricum
Akkermansia muciniphila
inflammatory bowel disease
colitis-associated colorectal cancer
Online Access:https://journals.asm.org/doi/10.1128/msystems.01567-24
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