Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief
Several studies have suggested that probiotics could play a role in the management of patients with chronic bacterial prostatitis (CBP). In this randomized, placebo-controlled clinical study, we evaluated the efficacy and safety of consumption of probiotics containing human <i>Lactobacillus ca...
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2076-2607/13/1/130 |
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| author | Cristina Vocca Diana Marisol Abrego-Guandique Erika Cione Vincenzo Rania Gianmarco Marcianò Caterina Palleria Luca Catarisano Manuela Colosimo Gregorio La Cava Italo Michele Palumbo Giovambattista De Sarro Tommaso Ceccato Simone Botti Tommaso Cai Alessandro Palmieri Luca Gallelli |
| author_facet | Cristina Vocca Diana Marisol Abrego-Guandique Erika Cione Vincenzo Rania Gianmarco Marcianò Caterina Palleria Luca Catarisano Manuela Colosimo Gregorio La Cava Italo Michele Palumbo Giovambattista De Sarro Tommaso Ceccato Simone Botti Tommaso Cai Alessandro Palmieri Luca Gallelli |
| author_sort | Cristina Vocca |
| collection | DOAJ |
| description | Several studies have suggested that probiotics could play a role in the management of patients with chronic bacterial prostatitis (CBP). In this randomized, placebo-controlled clinical study, we evaluated the efficacy and safety of consumption of probiotics containing human <i>Lactobacillus casei</i> DG<sup>®</sup> as an add-on treatment in patients with clinical recurrences of CBP, through gut microbiota modification analysis. Enrolled patients with CBP were randomized to receive for 3 months probiotics containing human <i>Lactobacillus casei</i> DG<sup>®</sup> or placebo following 1 month treatment with ciprofloxacin. During the enrollment and follow-ups, urological examinations analyzed symptoms and quality of life, while microbiological tests analyzed gut and seminal microbiota. During the study, the development of adverse drug reactions was evaluated through the Naranjo scale. Twenty-four patients with CBP were recruited and treated for 3 months with placebo (n. 12) or with <i>Lactobacillus casei</i> DG<sup>®</sup> (n. 12). <i>Lactobacillus casei</i> DG<sup>®</sup> induced a significantly (<i>p</i> < 0.01) faster recovery of symptoms than placebo (2 days vs. 8 days) and an increased time free from symptoms (86 days vs. 42 days) without the occurrence of adverse events. In the probiotic group, the appearance of <i>Lactobacilli</i> after 30 days (T1) was higher vs. the placebo group, and a significant reduction in <i>Corynebacterium</i>, <i>Peptoniphilus</i>, <i>Pseudomonas</i>, <i>Veillonella</i>, <i>Staphylococcus,</i> and <i>Streptococcus</i> was also observed. These preliminary data suggest that in patients with CBP, the use of <i>Lactobacillus casei</i> DG after an antimicrobial treatment improves the days free of symptoms and the quality of life, without the development of adverse drug reactions. |
| format | Article |
| id | doaj-art-e34d2de2726048908e07eacb165bbef0 |
| institution | Kabale University |
| issn | 2076-2607 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Microorganisms |
| spelling | doaj-art-e34d2de2726048908e07eacb165bbef02025-01-24T13:42:45ZengMDPI AGMicroorganisms2076-26072025-01-0113113010.3390/microorganisms13010130Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom ReliefCristina Vocca0Diana Marisol Abrego-Guandique1Erika Cione2Vincenzo Rania3Gianmarco Marcianò4Caterina Palleria5Luca Catarisano6Manuela Colosimo7Gregorio La Cava8Italo Michele Palumbo9Giovambattista De Sarro10Tommaso Ceccato11Simone Botti12Tommaso Cai13Alessandro Palmieri14Luca Gallelli15Operative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Rende, ItalyOperative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Microbiology and Virology, AOU Dulbecco, 88100 Catanzaro, ItalyUrology Division Azienda Sanitaria Provinciale, Department of Primary Care, 88100 Catanzaro, ItalyDepartment of Urology, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyOperative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDepartment of Urology, Santa Chiara Regional Hospital, 38123 Trento, ItalyDepartment of Urology, Santa Chiara Regional Hospital, 38123 Trento, ItalyDepartment of Urology, Santa Chiara Regional Hospital, 38123 Trento, ItalyDepartment of Urology, Federico II University of Naples, 80138 Naples, ItalyOperative Unit of Clinical Pharmacology and Pharmacovigilance, Department of Health Science, AOU Dulbecco, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalySeveral studies have suggested that probiotics could play a role in the management of patients with chronic bacterial prostatitis (CBP). In this randomized, placebo-controlled clinical study, we evaluated the efficacy and safety of consumption of probiotics containing human <i>Lactobacillus casei</i> DG<sup>®</sup> as an add-on treatment in patients with clinical recurrences of CBP, through gut microbiota modification analysis. Enrolled patients with CBP were randomized to receive for 3 months probiotics containing human <i>Lactobacillus casei</i> DG<sup>®</sup> or placebo following 1 month treatment with ciprofloxacin. During the enrollment and follow-ups, urological examinations analyzed symptoms and quality of life, while microbiological tests analyzed gut and seminal microbiota. During the study, the development of adverse drug reactions was evaluated through the Naranjo scale. Twenty-four patients with CBP were recruited and treated for 3 months with placebo (n. 12) or with <i>Lactobacillus casei</i> DG<sup>®</sup> (n. 12). <i>Lactobacillus casei</i> DG<sup>®</sup> induced a significantly (<i>p</i> < 0.01) faster recovery of symptoms than placebo (2 days vs. 8 days) and an increased time free from symptoms (86 days vs. 42 days) without the occurrence of adverse events. In the probiotic group, the appearance of <i>Lactobacilli</i> after 30 days (T1) was higher vs. the placebo group, and a significant reduction in <i>Corynebacterium</i>, <i>Peptoniphilus</i>, <i>Pseudomonas</i>, <i>Veillonella</i>, <i>Staphylococcus,</i> and <i>Streptococcus</i> was also observed. These preliminary data suggest that in patients with CBP, the use of <i>Lactobacillus casei</i> DG after an antimicrobial treatment improves the days free of symptoms and the quality of life, without the development of adverse drug reactions.https://www.mdpi.com/2076-2607/13/1/130microbiotachronic bacterial prostatitisantibiotic resistance<i>Lactobacillus casei</i> DGprobiotics |
| spellingShingle | Cristina Vocca Diana Marisol Abrego-Guandique Erika Cione Vincenzo Rania Gianmarco Marcianò Caterina Palleria Luca Catarisano Manuela Colosimo Gregorio La Cava Italo Michele Palumbo Giovambattista De Sarro Tommaso Ceccato Simone Botti Tommaso Cai Alessandro Palmieri Luca Gallelli Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief Microorganisms microbiota chronic bacterial prostatitis antibiotic resistance <i>Lactobacillus casei</i> DG probiotics |
| title | Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief |
| title_full | Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief |
| title_fullStr | Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief |
| title_full_unstemmed | Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief |
| title_short | Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief |
| title_sort | probiotics in the management of chronic bacterial prostatitis patients a randomized double blind trial to evaluate a possible link between gut microbiota restoring and symptom relief |
| topic | microbiota chronic bacterial prostatitis antibiotic resistance <i>Lactobacillus casei</i> DG probiotics |
| url | https://www.mdpi.com/2076-2607/13/1/130 |
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