Probiotics in the Management of Chronic Bacterial Prostatitis Patients: A Randomized, Double-Blind Trial to Evaluate a Possible Link Between Gut Microbiota Restoring and Symptom Relief
Several studies have suggested that probiotics could play a role in the management of patients with chronic bacterial prostatitis (CBP). In this randomized, placebo-controlled clinical study, we evaluated the efficacy and safety of consumption of probiotics containing human <i>Lactobacillus ca...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Microorganisms |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-2607/13/1/130 |
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| Summary: | Several studies have suggested that probiotics could play a role in the management of patients with chronic bacterial prostatitis (CBP). In this randomized, placebo-controlled clinical study, we evaluated the efficacy and safety of consumption of probiotics containing human <i>Lactobacillus casei</i> DG<sup>®</sup> as an add-on treatment in patients with clinical recurrences of CBP, through gut microbiota modification analysis. Enrolled patients with CBP were randomized to receive for 3 months probiotics containing human <i>Lactobacillus casei</i> DG<sup>®</sup> or placebo following 1 month treatment with ciprofloxacin. During the enrollment and follow-ups, urological examinations analyzed symptoms and quality of life, while microbiological tests analyzed gut and seminal microbiota. During the study, the development of adverse drug reactions was evaluated through the Naranjo scale. Twenty-four patients with CBP were recruited and treated for 3 months with placebo (n. 12) or with <i>Lactobacillus casei</i> DG<sup>®</sup> (n. 12). <i>Lactobacillus casei</i> DG<sup>®</sup> induced a significantly (<i>p</i> < 0.01) faster recovery of symptoms than placebo (2 days vs. 8 days) and an increased time free from symptoms (86 days vs. 42 days) without the occurrence of adverse events. In the probiotic group, the appearance of <i>Lactobacilli</i> after 30 days (T1) was higher vs. the placebo group, and a significant reduction in <i>Corynebacterium</i>, <i>Peptoniphilus</i>, <i>Pseudomonas</i>, <i>Veillonella</i>, <i>Staphylococcus,</i> and <i>Streptococcus</i> was also observed. These preliminary data suggest that in patients with CBP, the use of <i>Lactobacillus casei</i> DG after an antimicrobial treatment improves the days free of symptoms and the quality of life, without the development of adverse drug reactions. |
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| ISSN: | 2076-2607 |