Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model.
<h4>Objective</h4>To investigate whether time-restricted feeding (TRF) can reduce blood pressure (BP) and improve cardiac structure and function in spontaneously hypertensive rats (SHRs) by regulating the renin-angiotensin system (RAS).<h4>Methods</h4>Wistar Kyoto rats and SH...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0321078 |
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| author | Xin Yi Razif Abas Raja Abdul Wafy Raja Muhammad Rooshdi Jie Yan Canzhang Liu Chongshuang Yang Teng Gao Weijing Sun Ummi Nadira Daut |
| author_facet | Xin Yi Razif Abas Raja Abdul Wafy Raja Muhammad Rooshdi Jie Yan Canzhang Liu Chongshuang Yang Teng Gao Weijing Sun Ummi Nadira Daut |
| author_sort | Xin Yi |
| collection | DOAJ |
| description | <h4>Objective</h4>To investigate whether time-restricted feeding (TRF) can reduce blood pressure (BP) and improve cardiac structure and function in spontaneously hypertensive rats (SHRs) by regulating the renin-angiotensin system (RAS).<h4>Methods</h4>Wistar Kyoto rats and SHR underwent 16 weeks of TRF intervention, with daily feeding restricted to 9 am-5 pm. The effects of TRF on systolic BP, diastolic BP, mean BP, body weight (BW), heart weight (HW), HW/BW ratio, cardiac structure and function, and RAS activity in the circulating and left ventricular (LV) tissues were investigated.<h4>Results</h4>TRF effectively reduced systolic BP, mean BP, diastolic BP, and BW; improved hypertension-induced cardiac structural and functional damage; and inhibited the ACE-Ang-II-AT1 axis in circulating and LV tissues.<h4>Conclusion</h4>TRF effectively inhibits RAS activity in both circulating and LV tissues, thereby lowering BP and mitigating structural and functional cardiac damage associated with hypertension. |
| format | Article |
| id | doaj-art-e34bfe835e954b07b5f7585622223b7d |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e34bfe835e954b07b5f7585622223b7d2025-08-20T02:26:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01204e032107810.1371/journal.pone.0321078Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model.Xin YiRazif AbasRaja Abdul Wafy Raja Muhammad RooshdiJie YanCanzhang LiuChongshuang YangTeng GaoWeijing SunUmmi Nadira Daut<h4>Objective</h4>To investigate whether time-restricted feeding (TRF) can reduce blood pressure (BP) and improve cardiac structure and function in spontaneously hypertensive rats (SHRs) by regulating the renin-angiotensin system (RAS).<h4>Methods</h4>Wistar Kyoto rats and SHR underwent 16 weeks of TRF intervention, with daily feeding restricted to 9 am-5 pm. The effects of TRF on systolic BP, diastolic BP, mean BP, body weight (BW), heart weight (HW), HW/BW ratio, cardiac structure and function, and RAS activity in the circulating and left ventricular (LV) tissues were investigated.<h4>Results</h4>TRF effectively reduced systolic BP, mean BP, diastolic BP, and BW; improved hypertension-induced cardiac structural and functional damage; and inhibited the ACE-Ang-II-AT1 axis in circulating and LV tissues.<h4>Conclusion</h4>TRF effectively inhibits RAS activity in both circulating and LV tissues, thereby lowering BP and mitigating structural and functional cardiac damage associated with hypertension.https://doi.org/10.1371/journal.pone.0321078 |
| spellingShingle | Xin Yi Razif Abas Raja Abdul Wafy Raja Muhammad Rooshdi Jie Yan Canzhang Liu Chongshuang Yang Teng Gao Weijing Sun Ummi Nadira Daut Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model. PLoS ONE |
| title | Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model. |
| title_full | Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model. |
| title_fullStr | Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model. |
| title_full_unstemmed | Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model. |
| title_short | Time-restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin-angiotensin systems in spontaneously hypertensive rat model. |
| title_sort | time restricted feeding reduced blood pressure and improved cardiac structure and function by regulating both circulating and local renin angiotensin systems in spontaneously hypertensive rat model |
| url | https://doi.org/10.1371/journal.pone.0321078 |
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