A left-lateralized dorsolateral prefrontal network for naming
Summary: The ability to connect the form and meaning of a concept, known as word retrieval, is fundamental to human communication. While various input modalities could lead to identical word retrieval, the exact neural dynamics supporting this process relevant to daily auditory discourse remain poor...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725004486 |
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| author | Leyao Yu Patricia Dugan Werner Doyle Orrin Devinsky Daniel Friedman Adeen Flinker |
| author_facet | Leyao Yu Patricia Dugan Werner Doyle Orrin Devinsky Daniel Friedman Adeen Flinker |
| author_sort | Leyao Yu |
| collection | DOAJ |
| description | Summary: The ability to connect the form and meaning of a concept, known as word retrieval, is fundamental to human communication. While various input modalities could lead to identical word retrieval, the exact neural dynamics supporting this process relevant to daily auditory discourse remain poorly understood. Here, we recorded neurosurgical electrocorticography (ECoG) data from 48 patients and dissociated two key language networks that highly overlap in time and space, critical for word retrieval. Using unsupervised temporal clustering techniques, we found a semantic processing network located in the middle and inferior frontal gyri. This network was distinct from an articulatory planning network in the inferior frontal and precentral gyri, which was invariant to input modalities. Functionally, we confirmed that the semantic processing network encodes word surprisal during sentence perception. These findings elucidate neurophysiological mechanisms underlying the processing of semantic auditory inputs ranging from passive language comprehension to conversational speech. |
| format | Article |
| id | doaj-art-e3497b48516f48c0b09977e8582cdfb9 |
| institution | OA Journals |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-e3497b48516f48c0b09977e8582cdfb92025-08-20T01:49:46ZengElsevierCell Reports2211-12472025-05-0144511567710.1016/j.celrep.2025.115677A left-lateralized dorsolateral prefrontal network for namingLeyao Yu0Patricia Dugan1Werner Doyle2Orrin Devinsky3Daniel Friedman4Adeen Flinker5Department of Biomedical Engineering, NYU Tandon School of Engineering, New York, NY 10016, USA; Corresponding authorDepartment of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USADepartment of Neurosurgery, NYU Grossman School of Medicine, New York, NY 10016, USADepartment of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USADepartment of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USADepartment of Biomedical Engineering, NYU Tandon School of Engineering, New York, NY 10016, USA; Department of Neurology, NYU Grossman School of Medicine, New York, NY 10016, USASummary: The ability to connect the form and meaning of a concept, known as word retrieval, is fundamental to human communication. While various input modalities could lead to identical word retrieval, the exact neural dynamics supporting this process relevant to daily auditory discourse remain poorly understood. Here, we recorded neurosurgical electrocorticography (ECoG) data from 48 patients and dissociated two key language networks that highly overlap in time and space, critical for word retrieval. Using unsupervised temporal clustering techniques, we found a semantic processing network located in the middle and inferior frontal gyri. This network was distinct from an articulatory planning network in the inferior frontal and precentral gyri, which was invariant to input modalities. Functionally, we confirmed that the semantic processing network encodes word surprisal during sentence perception. These findings elucidate neurophysiological mechanisms underlying the processing of semantic auditory inputs ranging from passive language comprehension to conversational speech.http://www.sciencedirect.com/science/article/pii/S2211124725004486CP: Neuroscience |
| spellingShingle | Leyao Yu Patricia Dugan Werner Doyle Orrin Devinsky Daniel Friedman Adeen Flinker A left-lateralized dorsolateral prefrontal network for naming Cell Reports CP: Neuroscience |
| title | A left-lateralized dorsolateral prefrontal network for naming |
| title_full | A left-lateralized dorsolateral prefrontal network for naming |
| title_fullStr | A left-lateralized dorsolateral prefrontal network for naming |
| title_full_unstemmed | A left-lateralized dorsolateral prefrontal network for naming |
| title_short | A left-lateralized dorsolateral prefrontal network for naming |
| title_sort | left lateralized dorsolateral prefrontal network for naming |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725004486 |
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