A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction
Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2010/730861 |
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| _version_ | 1832564019466076160 |
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| author | George F. Lasker Jason H. Maley Philip J. Kadowitz |
| author_facet | George F. Lasker Jason H. Maley Philip J. Kadowitz |
| author_sort | George F. Lasker |
| collection | DOAJ |
| description | Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite. |
| format | Article |
| id | doaj-art-e348d2d8a1224390a0eaa203db9447d9 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-e348d2d8a1224390a0eaa203db9447d92025-02-03T01:12:00ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422010-01-01201010.1155/2010/730861730861A Review of the Pathophysiology and Novel Treatments for Erectile DysfunctionGeorge F. Lasker0Jason H. Maley1Philip J. Kadowitz2Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, SL83, New Orleans, LA 70112-2699, USADepartment of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, SL83, New Orleans, LA 70112-2699, USADepartment of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, SL83, New Orleans, LA 70112-2699, USAErectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite.http://dx.doi.org/10.1155/2010/730861 |
| spellingShingle | George F. Lasker Jason H. Maley Philip J. Kadowitz A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction Advances in Pharmacological Sciences |
| title | A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction |
| title_full | A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction |
| title_fullStr | A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction |
| title_full_unstemmed | A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction |
| title_short | A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction |
| title_sort | review of the pathophysiology and novel treatments for erectile dysfunction |
| url | http://dx.doi.org/10.1155/2010/730861 |
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