Topical 5-fluorouracil application in management of odontogenic keratocysts
Aim & objectives: The aim of this study was to evaluate the efficacy of topical application of 5-fluorouracil (5-FU) after peripheral ostectomy, and compare it with other treatment modalities in the management of odontogenic keratocyst (OKC). Materials &methods: This prospective study wa...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426820301020 |
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| author | Parveen Akhter Lone Nisar Ahmed Wani Zubair Ahmed Janbaz Mehnaz Bibi Amit Kour |
| author_facet | Parveen Akhter Lone Nisar Ahmed Wani Zubair Ahmed Janbaz Mehnaz Bibi Amit Kour |
| author_sort | Parveen Akhter Lone |
| collection | DOAJ |
| description | Aim & objectives: The aim of this study was to evaluate the efficacy of topical application of 5-fluorouracil (5-FU) after peripheral ostectomy, and compare it with other treatment modalities in the management of odontogenic keratocyst (OKC). Materials &methods: This prospective study was conducted in the OMFS department for last seven years, wherein twenty seven patients of OKC were included and randomly allocated to the three treatment groups. Nine were treated by enucleation followed by application of modified carnoy solution (CS), eleven by peripheral ostectomy followed by application of 5-FU and eleven by segmental resection (SR). Follow-up ranged from 2 to 4 years to assess bone healing and record any recurrence of lesion. Results: Amongst twenty seven patients, eighteen were males and nine females, age range 20–66 years. The most common location of OKC was posterior mandible. Complications included nerve injury, swelling, infection, and recurrence (66.6% after modified CS). Functional and aesthetic compromise was seen in resection patients whereas application of 5-FU had minimal nerve injuries, infection, swelling, no recurrence with no compromise in aesthetics and function. Conclusion: Management of OKC by 5-FU is a novel surgical method having less morbidity, minimal recurrence, low cost, no functional or cosmetic deformity. |
| format | Article |
| id | doaj-art-e347b3f33d824161ae5afb73a53852aa |
| institution | OA Journals |
| issn | 2212-4268 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-e347b3f33d824161ae5afb73a53852aa2025-08-20T02:01:56ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682020-10-0110440440610.1016/j.jobcr.2020.07.008Topical 5-fluorouracil application in management of odontogenic keratocystsParveen Akhter Lone0Nisar Ahmed Wani1Zubair Ahmed Janbaz2Mehnaz Bibi3Amit Kour4Indira Gandhi Government Dental College Amphalla Jammu Affiliated to University of Jammu, India; Corresponding author.Consultant Pediatric Radio Diagnosis GB Pant Hospital Srinagar Kashmir Affiliated to University of Kashmir, IndiaHouse Surgeon OMFS, IGGDC, Jammu, IndiaHouse Surgeon OMFS, IGGDC, Jammu, IndiaHouse Surgeon OMFS, IGGDC, Jammu, IndiaAim & objectives: The aim of this study was to evaluate the efficacy of topical application of 5-fluorouracil (5-FU) after peripheral ostectomy, and compare it with other treatment modalities in the management of odontogenic keratocyst (OKC). Materials &methods: This prospective study was conducted in the OMFS department for last seven years, wherein twenty seven patients of OKC were included and randomly allocated to the three treatment groups. Nine were treated by enucleation followed by application of modified carnoy solution (CS), eleven by peripheral ostectomy followed by application of 5-FU and eleven by segmental resection (SR). Follow-up ranged from 2 to 4 years to assess bone healing and record any recurrence of lesion. Results: Amongst twenty seven patients, eighteen were males and nine females, age range 20–66 years. The most common location of OKC was posterior mandible. Complications included nerve injury, swelling, infection, and recurrence (66.6% after modified CS). Functional and aesthetic compromise was seen in resection patients whereas application of 5-FU had minimal nerve injuries, infection, swelling, no recurrence with no compromise in aesthetics and function. Conclusion: Management of OKC by 5-FU is a novel surgical method having less morbidity, minimal recurrence, low cost, no functional or cosmetic deformity.http://www.sciencedirect.com/science/article/pii/S2212426820301020Conservative management5-Fluorouracil5-FUOKCMultilocularCarnoy solution |
| spellingShingle | Parveen Akhter Lone Nisar Ahmed Wani Zubair Ahmed Janbaz Mehnaz Bibi Amit Kour Topical 5-fluorouracil application in management of odontogenic keratocysts Journal of Oral Biology and Craniofacial Research Conservative management 5-Fluorouracil 5-FU OKC Multilocular Carnoy solution |
| title | Topical 5-fluorouracil application in management of odontogenic keratocysts |
| title_full | Topical 5-fluorouracil application in management of odontogenic keratocysts |
| title_fullStr | Topical 5-fluorouracil application in management of odontogenic keratocysts |
| title_full_unstemmed | Topical 5-fluorouracil application in management of odontogenic keratocysts |
| title_short | Topical 5-fluorouracil application in management of odontogenic keratocysts |
| title_sort | topical 5 fluorouracil application in management of odontogenic keratocysts |
| topic | Conservative management 5-Fluorouracil 5-FU OKC Multilocular Carnoy solution |
| url | http://www.sciencedirect.com/science/article/pii/S2212426820301020 |
| work_keys_str_mv | AT parveenakhterlone topical5fluorouracilapplicationinmanagementofodontogenickeratocysts AT nisarahmedwani topical5fluorouracilapplicationinmanagementofodontogenickeratocysts AT zubairahmedjanbaz topical5fluorouracilapplicationinmanagementofodontogenickeratocysts AT mehnazbibi topical5fluorouracilapplicationinmanagementofodontogenickeratocysts AT amitkour topical5fluorouracilapplicationinmanagementofodontogenickeratocysts |