AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

AARS2, an alanyl-tRNA synthase, is essential for protein translation, but its function in mouse hearts is not fully addressed. Here, we found that cardiomyocyte-specific deletion of mouse AARS2 exhibited evident cardiomyopathy with impaired cardiac function, notable cardiac fibrosis, and cardiomyocy...

Full description

Saved in:
Bibliographic Details
Main Authors: Zongwang Zhang, Lixia Zheng, Yang Chen, Yuanyuan Chen, Junjie Hou, Chenglu Xiao, Xiaojun Zhu, Shi-Min Zhao, Jing-Wei Xiong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-05-01
Series:eLife
Subjects:
AARS2
PKM2
cardiomyocytes
glycolysis
cardiac remodeling
Online Access:https://elifesciences.org/articles/99670
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://elifesciences.org/articles/99670

Similar Items