Campylobacter jejuni causes colorectal cancer
The incidence of colorectal cancer (CRC) has drastically increased in several Asian countries during the past four decades. These rapid epidemiological variations suggest that environmental parameters contribute to neoplastic transformation within the intestinal epithelium. A Western type of diet (r...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | World Journal of Colorectal Surgery |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/wjcs.wjcs_19_22 |
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| _version_ | 1850176172626804736 |
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| author | Pascal Alain Gervaz Álvaro De Campos Alberto Caeiro |
| author_facet | Pascal Alain Gervaz Álvaro De Campos Alberto Caeiro |
| author_sort | Pascal Alain Gervaz |
| collection | DOAJ |
| description | The incidence of colorectal cancer (CRC) has drastically increased in several Asian countries during the past four decades. These rapid epidemiological variations suggest that environmental parameters contribute to neoplastic transformation within the intestinal epithelium. A Western type of diet (rich in animal fat and proteins) is a recognized risk factor. In addition, there is a strong link between the type of diet and composition of the microbiota. These findings suggest that some bacteria may contribute to neoplastic transformation in the colon and rectum. However, a causal relationship between a specific microorganism and the development of CRC remains elusive. In this paper, we recapitulate the clinical evidence, suggesting that epigenetic transformation mediated by commensal bacteria is a prerequisite for tumor development in the large bowel. We review the experimental evidence, suggesting that a type of Campylobacter is likely to be involved in this neoplastic process. Campylobacter is highly prevalent in modern cattle and poultry farms and has the capacity to adhere to the colonic epithelium and contribute to genomic instability by releasing DNA-damaging toxins. Therefore, we hypothesize that the Campylobacter/Helicobacter group of bacteria may play a role in development of the two most common neoplasia of the digestive tract, i.e. adenocarcinoma of the colon and stomach, respectively. |
| format | Article |
| id | doaj-art-e340dbf30efe45e3b5fa5d627b106c78 |
| institution | OA Journals |
| issn | 1941-8213 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | World Journal of Colorectal Surgery |
| spelling | doaj-art-e340dbf30efe45e3b5fa5d627b106c782025-08-20T02:19:18ZengWolters Kluwer Medknow PublicationsWorld Journal of Colorectal Surgery1941-82132022-01-011114710.4103/wjcs.wjcs_19_22Campylobacter jejuni causes colorectal cancerPascal Alain GervazÁlvaro De CamposAlberto CaeiroThe incidence of colorectal cancer (CRC) has drastically increased in several Asian countries during the past four decades. These rapid epidemiological variations suggest that environmental parameters contribute to neoplastic transformation within the intestinal epithelium. A Western type of diet (rich in animal fat and proteins) is a recognized risk factor. In addition, there is a strong link between the type of diet and composition of the microbiota. These findings suggest that some bacteria may contribute to neoplastic transformation in the colon and rectum. However, a causal relationship between a specific microorganism and the development of CRC remains elusive. In this paper, we recapitulate the clinical evidence, suggesting that epigenetic transformation mediated by commensal bacteria is a prerequisite for tumor development in the large bowel. We review the experimental evidence, suggesting that a type of Campylobacter is likely to be involved in this neoplastic process. Campylobacter is highly prevalent in modern cattle and poultry farms and has the capacity to adhere to the colonic epithelium and contribute to genomic instability by releasing DNA-damaging toxins. Therefore, we hypothesize that the Campylobacter/Helicobacter group of bacteria may play a role in development of the two most common neoplasia of the digestive tract, i.e. adenocarcinoma of the colon and stomach, respectively.https://journals.lww.com/10.4103/wjcs.wjcs_19_22colorectal cancereco-cancerfamilial polyposis syndromehelicobacter pylorimicrobiota |
| spellingShingle | Pascal Alain Gervaz Álvaro De Campos Alberto Caeiro Campylobacter jejuni causes colorectal cancer World Journal of Colorectal Surgery colorectal cancer eco-cancer familial polyposis syndrome helicobacter pylori microbiota |
| title | Campylobacter jejuni causes colorectal cancer |
| title_full | Campylobacter jejuni causes colorectal cancer |
| title_fullStr | Campylobacter jejuni causes colorectal cancer |
| title_full_unstemmed | Campylobacter jejuni causes colorectal cancer |
| title_short | Campylobacter jejuni causes colorectal cancer |
| title_sort | campylobacter jejuni causes colorectal cancer |
| topic | colorectal cancer eco-cancer familial polyposis syndrome helicobacter pylori microbiota |
| url | https://journals.lww.com/10.4103/wjcs.wjcs_19_22 |
| work_keys_str_mv | AT pascalalaingervaz campylobacterjejunicausescolorectalcancer AT alvarodecampos campylobacterjejunicausescolorectalcancer AT albertocaeiro campylobacterjejunicausescolorectalcancer |