The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment
Abstract Background Combined with systemic therapy, the surgical intervention for breast cancer liver metastases (BCLM) is increasingly accepted but lacks convincing evidence. The aim of this study was to evaluate the disease control efficacy of hepatic surgery in isolated BCLM patients. Methods Bet...
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| Format: | Article |
| Language: | English |
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Wiley
2020-07-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.3117 |
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| author | Jiahuai Wen Feng Ye Fengfeng Xie Dan Liu LeZhen Huang Chen Fang Shaowen Zhong Liping Ren |
| author_facet | Jiahuai Wen Feng Ye Fengfeng Xie Dan Liu LeZhen Huang Chen Fang Shaowen Zhong Liping Ren |
| author_sort | Jiahuai Wen |
| collection | DOAJ |
| description | Abstract Background Combined with systemic therapy, the surgical intervention for breast cancer liver metastases (BCLM) is increasingly accepted but lacks convincing evidence. The aim of this study was to evaluate the disease control efficacy of hepatic surgery in isolated BCLM patients. Methods Between 2012 and 2017, metastatic breast cancer patients with isolated liver metastasis and regular follow‐up were identified. Cohort design was conducted to compare the progression‐free survival (PFS) between the surgical and nonsurgical BCLM patients. Univariate analysis and multivariate Cox regression survival analyses were performed to identify significant prognostic factors. Result In all, 148 isolated BCLM patients were enrolled and 95 participants received hepatic surgery for metastatic lesions. With median follow‐up of 36.47 months, there was no significant difference between hepatic surgical group and nonsurgical group for PFS (median PFS: 11.17 months vs 10.10 m, P = .092). Based on the multivariate analysis, the disease‐free interval (DFI) was an independent prognostic factor for isolated BCLM patients. Among the surgical group, BCLM patients who had ideal response after first salvage systemic treatment experienced the best long‐term survival (median PFS: 14.20 months). Conclusion For isolated BCLM patients with ideal response in first‐line medical treatment, surgical intervention (hepatectomy, radiofrequency ablation) combining with systemic treatment could bring improved progression‐free survival compared to sole systemic treatment, indicating that hepatic surgery may be considered as a therapeutic choice for selected isolated BCLM patients in clinical practice. |
| format | Article |
| id | doaj-art-e33f7d82953e4c4c88f58ef76b2514e2 |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-e33f7d82953e4c4c88f58ef76b2514e22025-08-20T02:40:11ZengWileyCancer Medicine2045-76342020-07-019134656466610.1002/cam4.3117The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatmentJiahuai Wen0Feng Ye1Fengfeng Xie2Dan Liu3LeZhen Huang4Chen Fang5Shaowen Zhong6Liping Ren7Department of Breast Oncology Guangdong Hospital of Traditional Chinese Medicine Guangzhou ChinaDepartment of Breast Oncology Sun Yat‐Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou ChinaDepartment of Breast Oncology Guangdong Hospital of Traditional Chinese Medicine Guangzhou ChinaDepartment of Breast Oncology Guangdong Hospital of Traditional Chinese Medicine Guangzhou ChinaDepartment of Breast Oncology Guangdong Hospital of Traditional Chinese Medicine Guangzhou ChinaDepartment of Breast Oncology Guangdong Hospital of Traditional Chinese Medicine Guangzhou ChinaDepartment of Breast Oncology Guangdong Hospital of Traditional Chinese Medicine Guangzhou ChinaDepartment of Breast Oncology Guangdong Hospital of Traditional Chinese Medicine Guangzhou ChinaAbstract Background Combined with systemic therapy, the surgical intervention for breast cancer liver metastases (BCLM) is increasingly accepted but lacks convincing evidence. The aim of this study was to evaluate the disease control efficacy of hepatic surgery in isolated BCLM patients. Methods Between 2012 and 2017, metastatic breast cancer patients with isolated liver metastasis and regular follow‐up were identified. Cohort design was conducted to compare the progression‐free survival (PFS) between the surgical and nonsurgical BCLM patients. Univariate analysis and multivariate Cox regression survival analyses were performed to identify significant prognostic factors. Result In all, 148 isolated BCLM patients were enrolled and 95 participants received hepatic surgery for metastatic lesions. With median follow‐up of 36.47 months, there was no significant difference between hepatic surgical group and nonsurgical group for PFS (median PFS: 11.17 months vs 10.10 m, P = .092). Based on the multivariate analysis, the disease‐free interval (DFI) was an independent prognostic factor for isolated BCLM patients. Among the surgical group, BCLM patients who had ideal response after first salvage systemic treatment experienced the best long‐term survival (median PFS: 14.20 months). Conclusion For isolated BCLM patients with ideal response in first‐line medical treatment, surgical intervention (hepatectomy, radiofrequency ablation) combining with systemic treatment could bring improved progression‐free survival compared to sole systemic treatment, indicating that hepatic surgery may be considered as a therapeutic choice for selected isolated BCLM patients in clinical practice.https://doi.org/10.1002/cam4.3117breast cancerliver metastasissurgical intervention |
| spellingShingle | Jiahuai Wen Feng Ye Fengfeng Xie Dan Liu LeZhen Huang Chen Fang Shaowen Zhong Liping Ren The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment Cancer Medicine breast cancer liver metastasis surgical intervention |
| title | The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment |
| title_full | The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment |
| title_fullStr | The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment |
| title_full_unstemmed | The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment |
| title_short | The role of surgical intervention for isolated breast cancer liver metastasis: Results of case‐control study with comparison to medical treatment |
| title_sort | role of surgical intervention for isolated breast cancer liver metastasis results of case control study with comparison to medical treatment |
| topic | breast cancer liver metastasis surgical intervention |
| url | https://doi.org/10.1002/cam4.3117 |
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