Personality-based intergenerational effects of prenatal THC exposure in an inherited mouse model of social dominance and submissiveness

Personality-based intergenerational effects of prenatal THC exposure in an inherited mouse model of social dominance and submissiveness

Abstract This study examines how stress-coping phenotypes influence the effect of prenatal $$\:\varDelta\:$$ 9-tetrahydrocannabinol (THC) exposure (PTE) on selectively bred Dominant (Dom) and Submissive (Sub) mice offspring exhibiting stress resilience and vulnerability, respectively. Pregnant Dom a...

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Main Authors: Mohamed Mari, Anastasia Bagaev, Debpali Sur, Beatriz G. S. Rocha, Dilorom Begmatova, Natalia Zemliana, Abdalla Bowirrat, Kenneth Blum, Panayotis K. Thanos, Natalya M. Kogan, Albert Pinhasov
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
THC
Prenatal development
Stress resilience
Endocannabinoid system (ECS)
Social behavior
Dopaminergic system (DAs)
Online Access:https://doi.org/10.1038/s41598-025-15528-1
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