Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury
Objective To investigate the effectiveness of continuous plasma filtration combined with plasma adsorption in the treatment of acute renal injury caused by sepsis. Methods 124 cases of septic AKI were randomly divided into experimental group and control group( 62 cases in each group). The control gr...
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Editorial Department of Journal of Clinical Nephrology
2017-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | TANG Jian-ying WANG Dai-hong WANG Yi-qing LI Mo-qi ZHAO Jing-hong |
| author_facet | TANG Jian-ying WANG Dai-hong WANG Yi-qing LI Mo-qi ZHAO Jing-hong |
| author_sort | TANG Jian-ying |
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| description | Objective To investigate the effectiveness of continuous plasma filtration combined with plasma adsorption in the treatment of acute renal injury caused by sepsis. Methods 124 cases of septic AKI were randomly divided into experimental group and control group( 62 cases in each group). The control group was given continuous hemofiltration treatment for 24 ~ 72 h and 150 ~ 180 ml/min of blood fluid,and the experimental group was given continuous plasma filtration( 24 ~ 72 h) combined with plasma adsorption( 3 h) and 150 ~ 180 ml/min of blood fluid. The 28-day survival rate,ICU stay and ventilator dependent time were compared between two groups,and the levels of IL-6,TNF-alpha,IL-1beta,IL-10,blood creatinine and blood urea nitrogen,vital signs,oxygenation index,white blood cell count,APACHE II score werecompared before and after treatment. Results The levels of IL-6,TNF-alpha,IL-1beta,IL-10,blood creatinine and blood urea nitrogen,vital signs,oxygenation index,white blood cell count,and APACHE II score were significantly improved after treatment in the two groups. The 28-day survival rate in the experimental group( 72. 58%) was significantly higher than in the control group( 46. 77%). ICU stay( 15. 69 ±3. 51 vs 18. 92 ± 3. 27 days) and ventilator dependent time( 4. 68 ± 3. 10 vs 6. 83 ± 3. 21 days) were significantly shorter in the experimental group than in the control group( P < 0. 05). The levels of IL-6( 62. 63 ±45. 25 vs 112. 38 ± 66. 23 ng/ml),TNF-alpha( 23. 62 ± 4. 27 vs 34. 82 ± 5. 29 ng/ml) and IL-1 beta( 32. 52 ± 8. 32 vs 46. 15 ± 9. 52 ng/mL) and IL-10( 295. 21 ± 106. 28 vs 361. 78 ± 102. 03 ng/ml) in the experimental group after treatment were significantly lower than in the control group( P < 0. 05). Blood creatinine( 61. 47 ± 10. 65 vs 79. 30 ± 11. 75 μmol/L) and blood urea nitrogen( 8. 69 ± 3. 61 vs 14. 06 ± 3. 76mmol/L) were significantly reduced,vital signs were significantly improved,white blood cell count( 11. 80± 4. 51 × 10~9/L vs 14. 53 ± 5. 09 × 10~9/L) and APACHE II score( 11. 62 ± 3. 71 vs 14. 36 ± 3. 52) significantly increased,and the oxygenation index( 362. 56 ± 98. 25 vs 82. 84 ± 105. 38) significantly decreased in the experimental group after treatment as compared with those in the control group( P < 0. 05). Conclusions Continuous plasma filtration combined with plasma adsorption therapy can effectively reduce the level of inflammatory cytokines in patients with septic AKI,alleviate inflammation and improve the prognosis of patients. |
| format | Article |
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| issn | 1671-2390 |
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| publishDate | 2017-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| spelling | doaj-art-e33dad697c77457991ba8a4d5d9a12a22025-08-20T02:16:10ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902017-01-0146647057916121Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injuryTANG Jian-yingWANG Dai-hongWANG Yi-qingLI Mo-qiZHAO Jing-hongObjective To investigate the effectiveness of continuous plasma filtration combined with plasma adsorption in the treatment of acute renal injury caused by sepsis. Methods 124 cases of septic AKI were randomly divided into experimental group and control group( 62 cases in each group). The control group was given continuous hemofiltration treatment for 24 ~ 72 h and 150 ~ 180 ml/min of blood fluid,and the experimental group was given continuous plasma filtration( 24 ~ 72 h) combined with plasma adsorption( 3 h) and 150 ~ 180 ml/min of blood fluid. The 28-day survival rate,ICU stay and ventilator dependent time were compared between two groups,and the levels of IL-6,TNF-alpha,IL-1beta,IL-10,blood creatinine and blood urea nitrogen,vital signs,oxygenation index,white blood cell count,APACHE II score werecompared before and after treatment. Results The levels of IL-6,TNF-alpha,IL-1beta,IL-10,blood creatinine and blood urea nitrogen,vital signs,oxygenation index,white blood cell count,and APACHE II score were significantly improved after treatment in the two groups. The 28-day survival rate in the experimental group( 72. 58%) was significantly higher than in the control group( 46. 77%). ICU stay( 15. 69 ±3. 51 vs 18. 92 ± 3. 27 days) and ventilator dependent time( 4. 68 ± 3. 10 vs 6. 83 ± 3. 21 days) were significantly shorter in the experimental group than in the control group( P < 0. 05). The levels of IL-6( 62. 63 ±45. 25 vs 112. 38 ± 66. 23 ng/ml),TNF-alpha( 23. 62 ± 4. 27 vs 34. 82 ± 5. 29 ng/ml) and IL-1 beta( 32. 52 ± 8. 32 vs 46. 15 ± 9. 52 ng/mL) and IL-10( 295. 21 ± 106. 28 vs 361. 78 ± 102. 03 ng/ml) in the experimental group after treatment were significantly lower than in the control group( P < 0. 05). Blood creatinine( 61. 47 ± 10. 65 vs 79. 30 ± 11. 75 μmol/L) and blood urea nitrogen( 8. 69 ± 3. 61 vs 14. 06 ± 3. 76mmol/L) were significantly reduced,vital signs were significantly improved,white blood cell count( 11. 80± 4. 51 × 10~9/L vs 14. 53 ± 5. 09 × 10~9/L) and APACHE II score( 11. 62 ± 3. 71 vs 14. 36 ± 3. 52) significantly increased,and the oxygenation index( 362. 56 ± 98. 25 vs 82. 84 ± 105. 38) significantly decreased in the experimental group after treatment as compared with those in the control group( P < 0. 05). Conclusions Continuous plasma filtration combined with plasma adsorption therapy can effectively reduce the level of inflammatory cytokines in patients with septic AKI,alleviate inflammation and improve the prognosis of patients.http://www.lcszb.com/thesisDetails?columnId=57916121&Fpath=home&index=0Continuous plasma filtrationPlasma adsorptionSepsisAcute renal injury |
| spellingShingle | TANG Jian-ying WANG Dai-hong WANG Yi-qing LI Mo-qi ZHAO Jing-hong Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury Linchuang shenzangbing zazhi Continuous plasma filtration Plasma adsorption Sepsis Acute renal injury |
| title | Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury |
| title_full | Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury |
| title_fullStr | Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury |
| title_full_unstemmed | Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury |
| title_short | Effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury |
| title_sort | effectiveness of continuous plasma filtration combined with plasma adsorption for the septic acute kidney injury |
| topic | Continuous plasma filtration Plasma adsorption Sepsis Acute renal injury |
| url | http://www.lcszb.com/thesisDetails?columnId=57916121&Fpath=home&index=0 |
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