The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease
In this study, we aimed to evaluate the role of cardiac troponin T (cTnT) in detecting myocardial involvement in children with chronic kidney disease (CKD) and to investigate whether it contributes to predicting cardiac involvement and mortality at follow-up. Echocardiographic evaluations were perf...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2019-12-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/786 |
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| author | Ulaş Karadaş Nihal Özdemir Karadaş Mustafa Bak Erkin Serdaroğlu Murat Muhtar Yılmazer Timur Meşe |
| author_facet | Ulaş Karadaş Nihal Özdemir Karadaş Mustafa Bak Erkin Serdaroğlu Murat Muhtar Yılmazer Timur Meşe |
| author_sort | Ulaş Karadaş |
| collection | DOAJ |
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In this study, we aimed to evaluate the role of cardiac troponin T (cTnT) in detecting myocardial involvement in children with chronic kidney disease (CKD) and to investigate whether it contributes to predicting cardiac involvement and mortality at follow-up. Echocardiographic evaluations were performed on a sample of 69 patients, of which 33 (47.8%) were female, with grade 3, 4 and 5 chronic renal failure and end-stage renal failure. Patients with normal cTnT levels and patients with high cTnT levels were compared. cTnT levels were observed to be high in 13 (19%) of the 69 patients. The comparison between the patients with normal cTnT levels and patients with high cTnT levels with regards to the echocardiographic findings revealed that in the latter group, the average ejection fraction and fractional shortening levels were lower (p=0.003 and p=0.013, respectively), the detection rate of left ventricular systolic dysfunction was 5.5 times higher and the rate of detection of left ventricular hypertrophy (LVH) was 3 times higher (p=0.004, p=0.011). In this study, it was shown that it is possible to obtain information about cardiac effects by examining the serum cTnT level before clinical symptoms occur in children with CKD, and that cTnT can be used for screening purposes.
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| format | Article |
| id | doaj-art-e33cd1341c004870ba36bae9e5e45b21 |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-e33cd1341c004870ba36bae9e5e45b212025-08-20T02:01:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212019-12-0161610.24953/turkjped.2019.06.008The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal diseaseUlaş Karadaş0Nihal Özdemir Karadaş1Mustafa Bak2Erkin Serdaroğlu3Murat Muhtar Yılmazer4Timur Meşe5Department of Pediatric Cardiology, İzmir Tepecik Research and Training Hospital.Divisions of Pediatric Nephrology , Dr. Behçet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Nephrology , Dr. Behçet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Nephrology , Dr. Behçet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Cardiology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey.Divisions of Pediatric Cardiology, Dr. Behçet Uz Children's Hospital, İzmir, Turkey. In this study, we aimed to evaluate the role of cardiac troponin T (cTnT) in detecting myocardial involvement in children with chronic kidney disease (CKD) and to investigate whether it contributes to predicting cardiac involvement and mortality at follow-up. Echocardiographic evaluations were performed on a sample of 69 patients, of which 33 (47.8%) were female, with grade 3, 4 and 5 chronic renal failure and end-stage renal failure. Patients with normal cTnT levels and patients with high cTnT levels were compared. cTnT levels were observed to be high in 13 (19%) of the 69 patients. The comparison between the patients with normal cTnT levels and patients with high cTnT levels with regards to the echocardiographic findings revealed that in the latter group, the average ejection fraction and fractional shortening levels were lower (p=0.003 and p=0.013, respectively), the detection rate of left ventricular systolic dysfunction was 5.5 times higher and the rate of detection of left ventricular hypertrophy (LVH) was 3 times higher (p=0.004, p=0.011). In this study, it was shown that it is possible to obtain information about cardiac effects by examining the serum cTnT level before clinical symptoms occur in children with CKD, and that cTnT can be used for screening purposes. https://turkjpediatr.org/article/view/786cardiac influencecardiac troponin Tchronic kidney disease |
| spellingShingle | Ulaş Karadaş Nihal Özdemir Karadaş Mustafa Bak Erkin Serdaroğlu Murat Muhtar Yılmazer Timur Meşe The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease The Turkish Journal of Pediatrics cardiac influence cardiac troponin T chronic kidney disease |
| title | The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease |
| title_full | The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease |
| title_fullStr | The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease |
| title_full_unstemmed | The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease |
| title_short | The role of cardiac troponin T in detection of cardiac damage and long term mortality in children with chronic renal disease |
| title_sort | role of cardiac troponin t in detection of cardiac damage and long term mortality in children with chronic renal disease |
| topic | cardiac influence cardiac troponin T chronic kidney disease |
| url | https://turkjpediatr.org/article/view/786 |
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