Podocyte A20/TNFAIP3 Controls Glomerulonephritis Severity via the Regulation of Inflammatory Responses and Effects on the Cytoskeleton

Podocyte A20/TNFAIP3 Controls Glomerulonephritis Severity via the Regulation of Inflammatory Responses and Effects on the Cytoskeleton

A20/Tnfaip3, an early NF-κB response gene and key negative regulator of NF-κB signaling, suppresses proinflammatory responses. Its ubiquitinase and deubiquitinase activities mediate proteasomal degradation within the NF-κB pathway. This study investigated the involvement of A20 signaling alterations...

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Bibliographic Details
Main Authors: Paulina Köhler, Andrea Ribeiro, Mohsen Honarpisheh, Ekaterina von Rauchhaupt, Georg Lorenz, Chenyu Li, Lucas Martin, Stefanie Steiger, Maja Lindenmeyer, Christoph Schmaderer, Hans-Joachim Anders, Dana Thomasova, Maciej Lech
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
A20
Tnfaip3
podocyte
inflammation
anoikis
Online Access:https://www.mdpi.com/2073-4409/14/5/381
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