Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis
Background: The investigation of the correlation between ABO blood groups and susceptibility to infectiousdiseases, particularly COVID-19 and Helicobacter pylori (H. pylori), has garnered significant scholarlyattention in recent studies. This study aimed to evaluate the association between ABO blood...
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| Format: | Article |
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Shiraz University of Medical Sciences
2025-03-01
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| Series: | Iranian Journal of Colorectal Research |
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| Online Access: | https://colorectalresearch.sums.ac.ir/article_50962_80387c9362c3854ddc7048ef75df1909.pdf |
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| author | Maryam Nejabat Mohammad Motamedifar Saeid Amiri Zadeh Fard |
| author_facet | Maryam Nejabat Mohammad Motamedifar Saeid Amiri Zadeh Fard |
| author_sort | Maryam Nejabat |
| collection | DOAJ |
| description | Background: The investigation of the correlation between ABO blood groups and susceptibility to infectiousdiseases, particularly COVID-19 and Helicobacter pylori (H. pylori), has garnered significant scholarlyattention in recent studies. This study aimed to evaluate the association between ABO blood groups and H.pylori infection with COVID-19 susceptibility and severity.Methods: This cross-sectional study was conducted from October 1, 2021 to March 31, 2023. During thisperiod, serum samples from 1,105 patients diagnosed with COVID-19 at hospitals affiliated with ShirazUniversity of Medical Sciences were analyzed for SARS-CoV-2 and H. pylori antibodies using the enzymelinkedimmunosorbent assay (ELISA) technique. Clinical data, including demographic characteristics andmanifestations of COVID-19, were collected through structured interviews and comprehensive reviews ofmedical records.Results: The prevalence of COVID-19 was significantly higher among individuals with blood group Acompared to other groups (P=0.032). Patients co-infected with H. pylori had more severe COVID-19 symptoms(P=0.021). The findings from this investigation reveal that blood group O is correlated with an increased riskfor both COVID-19 and H. pylori infections, whereas blood group AB demonstrates a reduced susceptibility toCOVID-19, although this does not imply definitive protective. Noteworthy associations were identified betweenABO blood groups and specific COVID-19 symptoms, including headache, chronic underlying conditions,chest discomfort, and sore throat. The hospitalization among patients with blood group AB was higher thanthat observed in other blood groups (10.8%), while it was notably lower in patients with blood group O (4.6%,P=0.038).Conclusion: Our findings suggest a significant association between ABO blood groups, H. pylori infection, andsusceptibility to COVID-19. These factors may contribute to disease severity and warrant further investigationfor potential clinical implications. |
| format | Article |
| id | doaj-art-e33c15b1920b481c9f090ffdb2b1a7e2 |
| institution | Kabale University |
| issn | 2783-2430 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Colorectal Research |
| spelling | doaj-art-e33c15b1920b481c9f090ffdb2b1a7e22025-08-20T04:22:06ZengShiraz University of Medical SciencesIranian Journal of Colorectal Research2783-24302025-03-011311710.30476/acrr.2025.106687.124550962Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional AnalysisMaryam Nejabat0Mohammad Motamedifar1Saeid Amiri Zadeh Fard2Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Bacteriology and Virology, Shiraz Medical School, Shiraz University Medical Science, Shiraz, IranGastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranBackground: The investigation of the correlation between ABO blood groups and susceptibility to infectiousdiseases, particularly COVID-19 and Helicobacter pylori (H. pylori), has garnered significant scholarlyattention in recent studies. This study aimed to evaluate the association between ABO blood groups and H.pylori infection with COVID-19 susceptibility and severity.Methods: This cross-sectional study was conducted from October 1, 2021 to March 31, 2023. During thisperiod, serum samples from 1,105 patients diagnosed with COVID-19 at hospitals affiliated with ShirazUniversity of Medical Sciences were analyzed for SARS-CoV-2 and H. pylori antibodies using the enzymelinkedimmunosorbent assay (ELISA) technique. Clinical data, including demographic characteristics andmanifestations of COVID-19, were collected through structured interviews and comprehensive reviews ofmedical records.Results: The prevalence of COVID-19 was significantly higher among individuals with blood group Acompared to other groups (P=0.032). Patients co-infected with H. pylori had more severe COVID-19 symptoms(P=0.021). The findings from this investigation reveal that blood group O is correlated with an increased riskfor both COVID-19 and H. pylori infections, whereas blood group AB demonstrates a reduced susceptibility toCOVID-19, although this does not imply definitive protective. Noteworthy associations were identified betweenABO blood groups and specific COVID-19 symptoms, including headache, chronic underlying conditions,chest discomfort, and sore throat. The hospitalization among patients with blood group AB was higher thanthat observed in other blood groups (10.8%), while it was notably lower in patients with blood group O (4.6%,P=0.038).Conclusion: Our findings suggest a significant association between ABO blood groups, H. pylori infection, andsusceptibility to COVID-19. These factors may contribute to disease severity and warrant further investigationfor potential clinical implications.https://colorectalresearch.sums.ac.ir/article_50962_80387c9362c3854ddc7048ef75df1909.pdfabo blood grouphelicobacter pyloricovid-19susceptibilityace2 receptor |
| spellingShingle | Maryam Nejabat Mohammad Motamedifar Saeid Amiri Zadeh Fard Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis Iranian Journal of Colorectal Research abo blood group helicobacter pylori covid-19 susceptibility ace2 receptor |
| title | Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis |
| title_full | Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis |
| title_fullStr | Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis |
| title_full_unstemmed | Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis |
| title_short | Effects of ABO Blood Groups and Helicobacter pylori on COVID-19 Susceptibility and Disease Severity: Findings from a Cross-Sectional Analysis |
| title_sort | effects of abo blood groups and helicobacter pylori on covid 19 susceptibility and disease severity findings from a cross sectional analysis |
| topic | abo blood group helicobacter pylori covid-19 susceptibility ace2 receptor |
| url | https://colorectalresearch.sums.ac.ir/article_50962_80387c9362c3854ddc7048ef75df1909.pdf |
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