Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review
ABSTRACT Objectives This study aims to summarize recent studies available on untargeted metabolomics employed for periodontitis diagnosis, from saliva and gingival crevicular fluid samples, to identify recurring metabolites with biomarker‐value potential. A secondary objective was to analysudurue th...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Clinical and Experimental Dental Research |
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| Online Access: | https://doi.org/10.1002/cre2.70095 |
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| author | Ana‐Maria Condor Andreea Iuliana Kui Smaranda Dana Buduru Marius Negucioiu Daniela Cornelia Condor Patricia‐Ondine Lucaciu |
| author_facet | Ana‐Maria Condor Andreea Iuliana Kui Smaranda Dana Buduru Marius Negucioiu Daniela Cornelia Condor Patricia‐Ondine Lucaciu |
| author_sort | Ana‐Maria Condor |
| collection | DOAJ |
| description | ABSTRACT Objectives This study aims to summarize recent studies available on untargeted metabolomics employed for periodontitis diagnosis, from saliva and gingival crevicular fluid samples, to identify recurring metabolites with biomarker‐value potential. A secondary objective was to analysudurue the protocols of existing studies, to facilitate further research. Material and Methods Three databases were electronically searched for relevant studies (PubMed, Web of Science, Scopus). Risk of bias assessment was performed using the Newcastle‐Ottawa scale (NOS). Data was extracted from studies, regarding general characteristics and conclusions, population characteristics, periodontal protocols, and metabolomics protocols. Metabolic pathway analysis was performed for recurrent metabolites. Results After screening 405 studies, 13 studies (10 using saliva samples, 3 using GCF samples) were included. 22 metabolites were identified in more than one study and included into the pathway analysis. Butyrate, lactate, isoleucine, glucose, pyruvate, isovalerate, hypoxanthine/xanthine, proline, valine, phenylalanine, and ethanol were most frequently encountered and were found upregulated in periodontitis patients compared to periodontally healthy patients. Conclusions Metabolomics could provide valuable opportunities in validating potential biomarkers or diagnosis panels, contributing to the screening, prognosis, progression and monitoring of periodontitis. Further studies on larger populations and using established protocols are needed. (PROSPERO CRD42023470339). |
| format | Article |
| id | doaj-art-e335da06c99a46cab47910daeb54de2f |
| institution | DOAJ |
| issn | 2057-4347 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Experimental Dental Research |
| spelling | doaj-art-e335da06c99a46cab47910daeb54de2f2025-08-20T03:18:41ZengWileyClinical and Experimental Dental Research2057-43472025-02-01111n/an/a10.1002/cre2.70095Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic ReviewAna‐Maria Condor0Andreea Iuliana Kui1Smaranda Dana Buduru2Marius Negucioiu3Daniela Cornelia Condor4Patricia‐Ondine Lucaciu5Department of Oral Rehabilitation, Faculty of Dental Medicine Oral Health Discipline Cluj‐Napoca RomaniaDepartment of Prosthodontics and Dental Materials, Faculty of Dental Medicine Prosthodontics Discipline Cluj‐Napoca RomaniaDepartment of Prosthodontics and Dental Materials, Faculty of Dental Medicine Prosthodontics Discipline Cluj‐Napoca RomaniaDepartment of Prosthodontics and Dental Materials, Faculty of Dental Medicine Prosthodontics Discipline Cluj‐Napoca RomaniaDepartment of Oral Rehabilitation, Faculty of Dental Medicine Periodontology Discipline Cluj‐Napoca RomaniaDepartment of Oral Rehabilitation, Faculty of Dental Medicine Oral Health Discipline Cluj‐Napoca RomaniaABSTRACT Objectives This study aims to summarize recent studies available on untargeted metabolomics employed for periodontitis diagnosis, from saliva and gingival crevicular fluid samples, to identify recurring metabolites with biomarker‐value potential. A secondary objective was to analysudurue the protocols of existing studies, to facilitate further research. Material and Methods Three databases were electronically searched for relevant studies (PubMed, Web of Science, Scopus). Risk of bias assessment was performed using the Newcastle‐Ottawa scale (NOS). Data was extracted from studies, regarding general characteristics and conclusions, population characteristics, periodontal protocols, and metabolomics protocols. Metabolic pathway analysis was performed for recurrent metabolites. Results After screening 405 studies, 13 studies (10 using saliva samples, 3 using GCF samples) were included. 22 metabolites were identified in more than one study and included into the pathway analysis. Butyrate, lactate, isoleucine, glucose, pyruvate, isovalerate, hypoxanthine/xanthine, proline, valine, phenylalanine, and ethanol were most frequently encountered and were found upregulated in periodontitis patients compared to periodontally healthy patients. Conclusions Metabolomics could provide valuable opportunities in validating potential biomarkers or diagnosis panels, contributing to the screening, prognosis, progression and monitoring of periodontitis. Further studies on larger populations and using established protocols are needed. (PROSPERO CRD42023470339).https://doi.org/10.1002/cre2.70095biomarkersmetabolomicsoral healthperiodontitis |
| spellingShingle | Ana‐Maria Condor Andreea Iuliana Kui Smaranda Dana Buduru Marius Negucioiu Daniela Cornelia Condor Patricia‐Ondine Lucaciu Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review Clinical and Experimental Dental Research biomarkers metabolomics oral health periodontitis |
| title | Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review |
| title_full | Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review |
| title_fullStr | Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review |
| title_full_unstemmed | Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review |
| title_short | Metabolomics Analysis as a Tool in Periodontitis Diagnosis: A Systematic Review |
| title_sort | metabolomics analysis as a tool in periodontitis diagnosis a systematic review |
| topic | biomarkers metabolomics oral health periodontitis |
| url | https://doi.org/10.1002/cre2.70095 |
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