Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?
Inflammation is a physiological mechanism of the immune response and has an important role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the participation of molecules produced by innate immunity cells in response to a variety of pathogen-associated molecular p...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2023/5584492 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849470588992618496 |
|---|---|
| author | Fabíola Silva Alves-Hanna Juniel Assis Crespo-Neto Glenda Menezes Nogueira Daniele Sá Pereira Amanda Barros Lima Thaís Lohana Pereira Ribeiro Vitória Giovanna Rodrigues Santos Joey Ramone Ferreira Fonseca Fábio Magalhães-Gama Aya Sadahiro Allyson Guimarães Costa |
| author_facet | Fabíola Silva Alves-Hanna Juniel Assis Crespo-Neto Glenda Menezes Nogueira Daniele Sá Pereira Amanda Barros Lima Thaís Lohana Pereira Ribeiro Vitória Giovanna Rodrigues Santos Joey Ramone Ferreira Fonseca Fábio Magalhães-Gama Aya Sadahiro Allyson Guimarães Costa |
| author_sort | Fabíola Silva Alves-Hanna |
| collection | DOAJ |
| description | Inflammation is a physiological mechanism of the immune response and has an important role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the participation of molecules produced by innate immunity cells in response to a variety of pathogen-associated molecular patterns and damage-associated molecular patterns is observed. However, chronic inflammation is intrinsically associated with leukemogenesis, as it induces DNA damage in hematopoietic stem cells and contributes to the creation of the preleukemic clone. Several factors influence the malignant transformation within the hematopoietic microenvironment, with inflammasomes having a crucial role in this process, in addition to acting in the regulation of hematopoiesis and its homeostasis. Inflammasomes are intracellular multimeric complexes responsible for the maturation and secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and the cell death process via pyroptosis. Therefore, dysregulation of the activation of these complexes may be a factor in triggering several diseases, including leukemias, and this has been the subject of several studies in the area. In this review, we summarized the current knowledge on the relationship between inflammation and leukemogenesis, in particular, the role of inflammasomes in different types of leukemias, and we describe the potential therapeutic targets directed at inflammasomes in the leukemic context. |
| format | Article |
| id | doaj-art-e3343338ddd34d51b271fda27ea98e61 |
| institution | Kabale University |
| issn | 2314-7156 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-e3343338ddd34d51b271fda27ea98e612025-08-20T03:25:07ZengWileyJournal of Immunology Research2314-71562023-01-01202310.1155/2023/5584492Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know?Fabíola Silva Alves-Hanna0Juniel Assis Crespo-Neto1Glenda Menezes Nogueira2Daniele Sá Pereira3Amanda Barros Lima4Thaís Lohana Pereira Ribeiro5Vitória Giovanna Rodrigues Santos6Joey Ramone Ferreira Fonseca7Fábio Magalhães-Gama8Aya Sadahiro9Allyson Guimarães Costa10Programa de Pós-Graduação em Imunologia Básica e AplicadaDiretoria de Ensino e PesquisaDiretoria de Ensino e PesquisaDiretoria de Ensino e PesquisaPrograma de Pós-Graduação em Imunologia Básica e AplicadaDiretoria de Ensino e PesquisaDiretoria de Ensino e PesquisaDiretoria de Ensino e PesquisaDiretoria de Ensino e PesquisaPrograma de Pós-Graduação em Imunologia Básica e AplicadaPrograma de Pós-Graduação em Imunologia Básica e AplicadaInflammation is a physiological mechanism of the immune response and has an important role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the participation of molecules produced by innate immunity cells in response to a variety of pathogen-associated molecular patterns and damage-associated molecular patterns is observed. However, chronic inflammation is intrinsically associated with leukemogenesis, as it induces DNA damage in hematopoietic stem cells and contributes to the creation of the preleukemic clone. Several factors influence the malignant transformation within the hematopoietic microenvironment, with inflammasomes having a crucial role in this process, in addition to acting in the regulation of hematopoiesis and its homeostasis. Inflammasomes are intracellular multimeric complexes responsible for the maturation and secretion of the proinflammatory cytokines interleukin-1β and interleukin-18 and the cell death process via pyroptosis. Therefore, dysregulation of the activation of these complexes may be a factor in triggering several diseases, including leukemias, and this has been the subject of several studies in the area. In this review, we summarized the current knowledge on the relationship between inflammation and leukemogenesis, in particular, the role of inflammasomes in different types of leukemias, and we describe the potential therapeutic targets directed at inflammasomes in the leukemic context.http://dx.doi.org/10.1155/2023/5584492 |
| spellingShingle | Fabíola Silva Alves-Hanna Juniel Assis Crespo-Neto Glenda Menezes Nogueira Daniele Sá Pereira Amanda Barros Lima Thaís Lohana Pereira Ribeiro Vitória Giovanna Rodrigues Santos Joey Ramone Ferreira Fonseca Fábio Magalhães-Gama Aya Sadahiro Allyson Guimarães Costa Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? Journal of Immunology Research |
| title | Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_full | Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_fullStr | Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_full_unstemmed | Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_short | Insights Regarding the Role of Inflammasomes in Leukemia: What Do We Know? |
| title_sort | insights regarding the role of inflammasomes in leukemia what do we know |
| url | http://dx.doi.org/10.1155/2023/5584492 |
| work_keys_str_mv | AT fabiolasilvaalveshanna insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT junielassiscresponeto insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT glendamenezesnogueira insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT danielesapereira insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT amandabarroslima insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT thaislohanapereiraribeiro insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT vitoriagiovannarodriguessantos insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT joeyramoneferreirafonseca insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT fabiomagalhaesgama insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT ayasadahiro insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow AT allysonguimaraescosta insightsregardingtheroleofinflammasomesinleukemiawhatdoweknow |