Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.

Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.

Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse model for BCC reveals that macrophages and dendriti...

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Main Authors: Simone König, Frauke Nitzki, Anja Uhmann, Kai Dittmann, Jennifer Theiss-Suennemann, Markus Herrmann, Holger M Reichardt, Reto Schwendener, Tobias Pukrop, Walter Schulz-Schaeffer, Heidi Hahn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093555&type=printable
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