Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.
Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse model for BCC reveals that macrophages and dendriti...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093555&type=printable |
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| author | Simone König Frauke Nitzki Anja Uhmann Kai Dittmann Jennifer Theiss-Suennemann Markus Herrmann Holger M Reichardt Reto Schwendener Tobias Pukrop Walter Schulz-Schaeffer Heidi Hahn |
| author_facet | Simone König Frauke Nitzki Anja Uhmann Kai Dittmann Jennifer Theiss-Suennemann Markus Herrmann Holger M Reichardt Reto Schwendener Tobias Pukrop Walter Schulz-Schaeffer Heidi Hahn |
| author_sort | Simone König |
| collection | DOAJ |
| description | Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse model for BCC reveals that macrophages and dendritic cells (DC) of the skin play an important role in BCC growth restraining processes. This is based on the observation that a clodronate-liposome mediated depletion of these cells in the tumor-bearing skin results in significant BCC enlargement. The depletion of these cells does not modulate Ki67 or K10 expression, but is accompanied by a decrease in collagen-producing cells in the tumor stroma. Together, the data suggest that cutaneous macrophages and DC in the tumor microenvironment exert an antitumor effect on BCC. |
| format | Article |
| id | doaj-art-e330aa80843a4dd0bbf5f0d15e43be40 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e330aa80843a4dd0bbf5f0d15e43be402025-08-20T02:15:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9355510.1371/journal.pone.0093555Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.Simone KönigFrauke NitzkiAnja UhmannKai DittmannJennifer Theiss-SuennemannMarkus HerrmannHolger M ReichardtReto SchwendenerTobias PukropWalter Schulz-SchaefferHeidi HahnBasal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse model for BCC reveals that macrophages and dendritic cells (DC) of the skin play an important role in BCC growth restraining processes. This is based on the observation that a clodronate-liposome mediated depletion of these cells in the tumor-bearing skin results in significant BCC enlargement. The depletion of these cells does not modulate Ki67 or K10 expression, but is accompanied by a decrease in collagen-producing cells in the tumor stroma. Together, the data suggest that cutaneous macrophages and DC in the tumor microenvironment exert an antitumor effect on BCC.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093555&type=printable |
| spellingShingle | Simone König Frauke Nitzki Anja Uhmann Kai Dittmann Jennifer Theiss-Suennemann Markus Herrmann Holger M Reichardt Reto Schwendener Tobias Pukrop Walter Schulz-Schaeffer Heidi Hahn Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice. PLoS ONE |
| title | Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice. |
| title_full | Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice. |
| title_fullStr | Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice. |
| title_full_unstemmed | Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice. |
| title_short | Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice. |
| title_sort | depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093555&type=printable |
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