Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management
Microscopic colitis (MC) encompasses the two morphologically distinct entities of collagenous colitis (CC) and lymphocytic colitis (LC). MC was first described less than 30 years ago but is presently recognized as a relatively common cause of chronic diarrhea in the adult population. Remarkably, up...
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| Format: | Article |
| Language: | English |
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Wiley
2003-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2003/404857 |
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| author | Ayman A Abdo Stefan J Urbanski Paul L Beck |
| author_facet | Ayman A Abdo Stefan J Urbanski Paul L Beck |
| author_sort | Ayman A Abdo |
| collection | DOAJ |
| description | Microscopic colitis (MC) encompasses the two morphologically distinct entities of collagenous colitis (CC) and lymphocytic colitis (LC). MC was first described less than 30 years ago but is presently recognized as a relatively common cause of chronic diarrhea in the adult population. Remarkably, up to 10% of adults who have a colonoscopy for the investigation of chronic diarrhea, and have endoscopically normal appearing mucosa, may have MC. Patients with MC generally present with chronic diarrhea, which can be associated with cramping and bloating. Endoscopic and radiological examinations are usually normal. Histological assessment reveals inflammation consisting predominantly of lymphocytic infiltration, and a thickened subepithelial collagen band is diagnostic of CC. Both LC and CC can be associated with autoimmune diseases such as celiac disease, diabetes, arthritis and thyroiditis, yet the mechanisms involved in the pathogenesis remain unclear. Emerging studies suggest that a stepwise approach be taken in the medical management of MC. This approach includes antidiarrheal agents and stopping of any offending agents; budesonide or bismuth subsalicylate; and cholestyramine or 5-acetylsalicylic acid agents. In resistant cases, oral corticosteroids and other immune modulatory therapy have been used. |
| format | Article |
| id | doaj-art-e33018dc54864a1390f36097a7225fcf |
| institution | OA Journals |
| issn | 0835-7900 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-e33018dc54864a1390f36097a7225fcf2025-08-20T02:21:23ZengWileyCanadian Journal of Gastroenterology0835-79002003-01-0117742543210.1155/2003/404857Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and ManagementAyman A Abdo0Stefan J Urbanski1Paul L Beck2Division of Gastroenterology, University of Calgary, Calgary, Alberta, CanadaDivision of Gastroenterology, University of Calgary, Calgary, Alberta, CanadaDivision of Gastroenterology, University of Calgary, Calgary, Alberta, CanadaMicroscopic colitis (MC) encompasses the two morphologically distinct entities of collagenous colitis (CC) and lymphocytic colitis (LC). MC was first described less than 30 years ago but is presently recognized as a relatively common cause of chronic diarrhea in the adult population. Remarkably, up to 10% of adults who have a colonoscopy for the investigation of chronic diarrhea, and have endoscopically normal appearing mucosa, may have MC. Patients with MC generally present with chronic diarrhea, which can be associated with cramping and bloating. Endoscopic and radiological examinations are usually normal. Histological assessment reveals inflammation consisting predominantly of lymphocytic infiltration, and a thickened subepithelial collagen band is diagnostic of CC. Both LC and CC can be associated with autoimmune diseases such as celiac disease, diabetes, arthritis and thyroiditis, yet the mechanisms involved in the pathogenesis remain unclear. Emerging studies suggest that a stepwise approach be taken in the medical management of MC. This approach includes antidiarrheal agents and stopping of any offending agents; budesonide or bismuth subsalicylate; and cholestyramine or 5-acetylsalicylic acid agents. In resistant cases, oral corticosteroids and other immune modulatory therapy have been used.http://dx.doi.org/10.1155/2003/404857 |
| spellingShingle | Ayman A Abdo Stefan J Urbanski Paul L Beck Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management Canadian Journal of Gastroenterology |
| title | Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management |
| title_full | Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management |
| title_fullStr | Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management |
| title_full_unstemmed | Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management |
| title_short | Lymphocytic and Collagenous Colitis: The Emerging Entity of Microscopic Colitis. An Update on Pathophysiology, Diagnosis and Management |
| title_sort | lymphocytic and collagenous colitis the emerging entity of microscopic colitis an update on pathophysiology diagnosis and management |
| url | http://dx.doi.org/10.1155/2003/404857 |
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