The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study
Background. The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoh...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
|
| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2019/5121574 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691167404326912 |
|---|---|
| author | Aya Kitae Yoshitaka Hashimoto Masahide Hamaguchi Akihiro Obora Takao Kojima Michiaki Fukui |
| author_facet | Aya Kitae Yoshitaka Hashimoto Masahide Hamaguchi Akihiro Obora Takao Kojima Michiaki Fukui |
| author_sort | Aya Kitae |
| collection | DOAJ |
| description | Background. The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD. Here we investigated whether the TyG-index can be used to predict incident NAFLD. Methods. This historical cohort study included 16,093 apparently healthy Japanese individuals. The TyG-index was calculated by the established formula: TyG = Ln [TG (mg/dl) × FPG (mg/dl)/2]. Fatty liver was diagnosed based on the subjects’ abdominal ultrasonography results. We divided the subjects into tertiles according to the levels of TyG-index. Hazard ratios (HRs) of the TyG-index for incident NAFLD were calculated by a Cox proportional hazards regression model. Results. During the observation period, 27.4% of the men and 11.0% of the women developed NAFLD. The highest TyG-index tertile (men, 8.48 ≤ TyG and women, 7.97 ≤ TyG) (adjusted HR 1.67, 95% CI 1.44–1.94, p<0.001 in the men and 2.06, 1.59–2.70, p<0.001 in the women) and the middle TyG-index tertile (men, 8.00 < TyG ≤ 8.48 and women, 7.53 <TyG ≤7.97) (1.33, 1.15–1.54, p<0.001 in the men and 1.52, 1.16–2.01, p<0.001 in the women) presented a significantly higher risk of incident NAFLD compared to the lowest TyG-index tertile (men, TyG < 8.00 and women, TyG < 7.53). Conclusions. Our findings demonstrate that the TyG-index is significantly associated with incident NAFLD. |
| format | Article |
| id | doaj-art-e32f801bff1a4f5495d8ab3bd2bbbd4f |
| institution | DOAJ |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-e32f801bff1a4f5495d8ab3bd2bbbd4f2025-08-20T03:21:07ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972019-01-01201910.1155/2019/51215745121574The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort StudyAya Kitae0Yoshitaka Hashimoto1Masahide Hamaguchi2Akihiro Obora3Takao Kojima4Michiaki Fukui5Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanDepartment of Gastroenterology, Asahi University Hospital, Gifu, JapanDepartment of Gastroenterology, Asahi University Hospital, Gifu, JapanDepartment of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, JapanBackground. The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD. Here we investigated whether the TyG-index can be used to predict incident NAFLD. Methods. This historical cohort study included 16,093 apparently healthy Japanese individuals. The TyG-index was calculated by the established formula: TyG = Ln [TG (mg/dl) × FPG (mg/dl)/2]. Fatty liver was diagnosed based on the subjects’ abdominal ultrasonography results. We divided the subjects into tertiles according to the levels of TyG-index. Hazard ratios (HRs) of the TyG-index for incident NAFLD were calculated by a Cox proportional hazards regression model. Results. During the observation period, 27.4% of the men and 11.0% of the women developed NAFLD. The highest TyG-index tertile (men, 8.48 ≤ TyG and women, 7.97 ≤ TyG) (adjusted HR 1.67, 95% CI 1.44–1.94, p<0.001 in the men and 2.06, 1.59–2.70, p<0.001 in the women) and the middle TyG-index tertile (men, 8.00 < TyG ≤ 8.48 and women, 7.53 <TyG ≤7.97) (1.33, 1.15–1.54, p<0.001 in the men and 1.52, 1.16–2.01, p<0.001 in the women) presented a significantly higher risk of incident NAFLD compared to the lowest TyG-index tertile (men, TyG < 8.00 and women, TyG < 7.53). Conclusions. Our findings demonstrate that the TyG-index is significantly associated with incident NAFLD.http://dx.doi.org/10.1155/2019/5121574 |
| spellingShingle | Aya Kitae Yoshitaka Hashimoto Masahide Hamaguchi Akihiro Obora Takao Kojima Michiaki Fukui The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study Canadian Journal of Gastroenterology and Hepatology |
| title | The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study |
| title_full | The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study |
| title_fullStr | The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study |
| title_full_unstemmed | The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study |
| title_short | The Triglyceride and Glucose Index Is a Predictor of Incident Nonalcoholic Fatty Liver Disease: A Population-Based Cohort Study |
| title_sort | triglyceride and glucose index is a predictor of incident nonalcoholic fatty liver disease a population based cohort study |
| url | http://dx.doi.org/10.1155/2019/5121574 |
| work_keys_str_mv | AT ayakitae thetriglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT yoshitakahashimoto thetriglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT masahidehamaguchi thetriglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT akihiroobora thetriglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT takaokojima thetriglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT michiakifukui thetriglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT ayakitae triglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT yoshitakahashimoto triglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT masahidehamaguchi triglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT akihiroobora triglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT takaokojima triglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy AT michiakifukui triglycerideandglucoseindexisapredictorofincidentnonalcoholicfattyliverdiseaseapopulationbasedcohortstudy |