Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease
Aim of investigation. To determine clinical and morphological features and mechanisms of development of gastroduodenal lesions at alcohol-induced disease of liver.Material and methods. Overall 137 patients with alcoholic disease of the liver were investigated. Clinical, endoscopic, morphological, im...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2010-11-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1564 |
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| author | I. V. Kozlova M. A. Suschenko |
| author_facet | I. V. Kozlova M. A. Suschenko |
| author_sort | I. V. Kozlova |
| collection | DOAJ |
| description | Aim of investigation. To determine clinical and morphological features and mechanisms of development of gastroduodenal lesions at alcohol-induced disease of liver.Material and methods. Overall 137 patients with alcoholic disease of the liver were investigated. Clinical, endoscopic, morphological, immunehistochemical diagnostic methods were applied.Results. Clinical, endoscopic and morphological features of gastroduodenal mucosa lesions in patients with alcohol-induced disease of the liver were revealed. Increase of morphometrical parameters of epithelial cells of stomach mucosa, immunepositive to nitric oxide synthase, endothelin-1, melatonin and glucagon, decrease of proliferative activity and increase of apoptosis of epithelial cells of stomach mucosa was found.Conclusion. Pattern of gastroduodenal lesions in many respects is determined by clinical and morphological variant of liver diseases, as well as by equivocal changes of diffuse endocrine system components and proliferative activity of stomach mucosa epithelial cells. |
| format | Article |
| id | doaj-art-e32c332a1b9448fdbc124079642cd654 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2010-11-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-e32c332a1b9448fdbc124079642cd6542025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732010-11-0120533381068Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver diseaseI. V. Kozlova0M. A. Suschenko1ГОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского Росздрава»ГОУ ВПО «Саратовский государственный медицинский университет им. В.И. Разумовского Росздрава»Aim of investigation. To determine clinical and morphological features and mechanisms of development of gastroduodenal lesions at alcohol-induced disease of liver.Material and methods. Overall 137 patients with alcoholic disease of the liver were investigated. Clinical, endoscopic, morphological, immunehistochemical diagnostic methods were applied.Results. Clinical, endoscopic and morphological features of gastroduodenal mucosa lesions in patients with alcohol-induced disease of the liver were revealed. Increase of morphometrical parameters of epithelial cells of stomach mucosa, immunepositive to nitric oxide synthase, endothelin-1, melatonin and glucagon, decrease of proliferative activity and increase of apoptosis of epithelial cells of stomach mucosa was found.Conclusion. Pattern of gastroduodenal lesions in many respects is determined by clinical and morphological variant of liver diseases, as well as by equivocal changes of diffuse endocrine system components and proliferative activity of stomach mucosa epithelial cells.https://www.gastro-j.ru/jour/article/view/1564alcohol-induced liver diseasegastroduodenal zonenitric oxide synthaseendothelin-1melatoninglucagonproliferative activityapoptosis |
| spellingShingle | I. V. Kozlova M. A. Suschenko Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии alcohol-induced liver disease gastroduodenal zone nitric oxide synthase endothelin-1 melatonin glucagon proliferative activity apoptosis |
| title | Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease |
| title_full | Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease |
| title_fullStr | Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease |
| title_full_unstemmed | Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease |
| title_short | Clinical and morphological features of gastroduodenal pathology at alcohol-induced liver disease |
| title_sort | clinical and morphological features of gastroduodenal pathology at alcohol induced liver disease |
| topic | alcohol-induced liver disease gastroduodenal zone nitric oxide synthase endothelin-1 melatonin glucagon proliferative activity apoptosis |
| url | https://www.gastro-j.ru/jour/article/view/1564 |
| work_keys_str_mv | AT ivkozlova clinicalandmorphologicalfeaturesofgastroduodenalpathologyatalcoholinducedliverdisease AT masuschenko clinicalandmorphologicalfeaturesofgastroduodenalpathologyatalcoholinducedliverdisease |