Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates

Multidrug efflux pumps of Pseudomonas aeruginosa show selectivity for their natural substrates

Antibiotic-resistant Gram-negative bacteria are an increasing threat to human health. Strategies to restore antibiotic efficacy include targeting multidrug efflux pumps by competitive efflux pump inhibitors. These could be derived from natural substrates of these efflux systems. In this work, we aim...

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Bibliographic Details
Main Authors:	Léna Mazza, Alexandre Bory, Alexandre Luscher, Joachim Kloehn, Jean-Luc Wolfender, Christian van Delden, Thilo Köhler
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-01-01
Series:	Frontiers in Microbiology
Subjects:	Pseudomonas aeruginosa antibiotic resistance multidrug efflux metabolomics natural substrates
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2024.1512472/full
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