Mitomycin C: An effective adjunct in the treatment of Ocular Surface Squamous Neoplasia
A 40 year old female patient presented with a mass in the right eye, foreign body sensation and redness in the right eye for 6 months. Examination revealed a mass in the interpalpebral area, located in the superonasal quadrant, involving the bulbar conjunctiva and cornea. The mass was papillomatous,...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-07-01
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| Series: | Delhi Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.7869/djo.488 |
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| Summary: | A 40 year old female patient presented with a mass in the right eye, foreign body sensation and redness in the right eye for 6 months. Examination revealed a mass in the interpalpebral area, located in the superonasal quadrant, involving the bulbar conjunctiva and cornea. The mass was papillomatous, having a strawberry appearance, with multiple feeder vessels and was sharply demarcated. Visual acuity in the right eye was 6/6p, with full range of ocular movements. The left eye with a visual acuity of 6/6p was normal. AS-OCT performed revealed hyper-reflectivity and a thickened epithelium in the right eye. Histopathological examination confirmed it to be an infiltrating squamous cell carcinoma with moderate differentiation. The lesion was subjected to a wide excision together with intra-operative Mitomycin C (MMC) used in a concentration of 0.04%. Two 1 week courses of topical MMC 0.04% were given post-operatively. The patient was examined at 6 monthly intervals and no recurrence has been observed till third follow-up.
Conclusion: Mitomycin –C is an effective adjuvant in the management of OSSN. |
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| ISSN: | 0972-0200 2454-2784 |