Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients
Objective To observe the curative effectiveness of Shengxuening? combined with erythropoietin vs.ferrous fumarate in the treatment of renal anemia of CKD non-dialysis patients to find the selective preference of treating renal anemia.Methods Fifty-eight patients with renal anemia were randomly divid...
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Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| author | GUO Ai-li |
| author_facet | GUO Ai-li |
| author_sort | GUO Ai-li |
| collection | DOAJ |
| description | Objective To observe the curative effectiveness of Shengxuening? combined with erythropoietin vs.ferrous fumarate in the treatment of renal anemia of CKD non-dialysis patients to find the selective preference of treating renal anemia.Methods Fifty-eight patients with renal anemia were randomly divided into Shengxuening group and ferrous fumarate group(n = 29 each).The course of the treatment lasted for 12 weeks.Both groups received same basic treatment(anti-hypertension,glycemia regulation,blood-lipid regulation,uric acid dropping,improvement of kidney circulation,maintainence of water and electrolyte balance,and use of EPO,etc).The changes of hemoglobin(Hb),hematocrit(Hct),serum ferritin(SF) and transferrin saturation(TAST),renal function,Alb,hs-CRP,erythropoietin dose,and the adverse reactions before and after treatment were observed.Results Hb,Hct,TSAT and SF in both groups were significantly increased and the dosage of erythropoietin was reduced after treatment(P<0.05).As compared with ferrous fumarate group,TSAT was increased significantly and the dosage of erythropoietin was reduced in Shengxuening group(P<0.05).No obvious adverse reactions occurred in Shengxuening group.In ferrous fumarate group,the adverse reactions occurred in 8 cases,including addominal discomfort,nausea,vomiting,etc.The incidence of adverse reactions was 33.3%.The hsCRP level was significantly increased in ferrous fumarate group(P<0.05).Conclusions Shengxuening can remarkably improve the iron metabolism and assist the treatment of renal anemia of CKD non-dialysis patients without obvious adverse reactions,and does not affect the micro-inflammatory state.The curative effectiveness of Shengxuening is more satisfactfory than that of ferrous fumarate. |
| format | Article |
| id | doaj-art-e3273c202c254eb7ab766d8759273ec2 |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2015-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-e3273c202c254eb7ab766d8759273ec22025-08-20T03:09:15ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902015-01-0128528857920617Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patientsGUO Ai-liObjective To observe the curative effectiveness of Shengxuening? combined with erythropoietin vs.ferrous fumarate in the treatment of renal anemia of CKD non-dialysis patients to find the selective preference of treating renal anemia.Methods Fifty-eight patients with renal anemia were randomly divided into Shengxuening group and ferrous fumarate group(n = 29 each).The course of the treatment lasted for 12 weeks.Both groups received same basic treatment(anti-hypertension,glycemia regulation,blood-lipid regulation,uric acid dropping,improvement of kidney circulation,maintainence of water and electrolyte balance,and use of EPO,etc).The changes of hemoglobin(Hb),hematocrit(Hct),serum ferritin(SF) and transferrin saturation(TAST),renal function,Alb,hs-CRP,erythropoietin dose,and the adverse reactions before and after treatment were observed.Results Hb,Hct,TSAT and SF in both groups were significantly increased and the dosage of erythropoietin was reduced after treatment(P<0.05).As compared with ferrous fumarate group,TSAT was increased significantly and the dosage of erythropoietin was reduced in Shengxuening group(P<0.05).No obvious adverse reactions occurred in Shengxuening group.In ferrous fumarate group,the adverse reactions occurred in 8 cases,including addominal discomfort,nausea,vomiting,etc.The incidence of adverse reactions was 33.3%.The hsCRP level was significantly increased in ferrous fumarate group(P<0.05).Conclusions Shengxuening can remarkably improve the iron metabolism and assist the treatment of renal anemia of CKD non-dialysis patients without obvious adverse reactions,and does not affect the micro-inflammatory state.The curative effectiveness of Shengxuening is more satisfactfory than that of ferrous fumarate.http://www.lcszb.com/thesisDetails?columnId=57920617&Fpath=home&index=0ShengxueningFerrous fumarateChronic kidney diseaseRenal anemia |
| spellingShingle | GUO Ai-li Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients Linchuang shenzangbing zazhi Shengxuening Ferrous fumarate Chronic kidney disease Renal anemia |
| title | Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients |
| title_full | Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients |
| title_fullStr | Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients |
| title_full_unstemmed | Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients |
| title_short | Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients |
| title_sort | curative effectiveness of shengxuening in the treatment of renal anemia of ckd non dialysis patients |
| topic | Shengxuening Ferrous fumarate Chronic kidney disease Renal anemia |
| url | http://www.lcszb.com/thesisDetails?columnId=57920617&Fpath=home&index=0 |
| work_keys_str_mv | AT guoaili curativeeffectivenessofshengxueninginthetreatmentofrenalanemiaofckdnondialysispatients |