Curative effectiveness of Shengxuening in the treatment of renal anemia of CKD non-dialysis patients
Objective To observe the curative effectiveness of Shengxuening? combined with erythropoietin vs.ferrous fumarate in the treatment of renal anemia of CKD non-dialysis patients to find the selective preference of treating renal anemia.Methods Fifty-eight patients with renal anemia were randomly divid...
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57920617&Fpath=home&index=0 |
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| Summary: | Objective To observe the curative effectiveness of Shengxuening? combined with erythropoietin vs.ferrous fumarate in the treatment of renal anemia of CKD non-dialysis patients to find the selective preference of treating renal anemia.Methods Fifty-eight patients with renal anemia were randomly divided into Shengxuening group and ferrous fumarate group(n = 29 each).The course of the treatment lasted for 12 weeks.Both groups received same basic treatment(anti-hypertension,glycemia regulation,blood-lipid regulation,uric acid dropping,improvement of kidney circulation,maintainence of water and electrolyte balance,and use of EPO,etc).The changes of hemoglobin(Hb),hematocrit(Hct),serum ferritin(SF) and transferrin saturation(TAST),renal function,Alb,hs-CRP,erythropoietin dose,and the adverse reactions before and after treatment were observed.Results Hb,Hct,TSAT and SF in both groups were significantly increased and the dosage of erythropoietin was reduced after treatment(P<0.05).As compared with ferrous fumarate group,TSAT was increased significantly and the dosage of erythropoietin was reduced in Shengxuening group(P<0.05).No obvious adverse reactions occurred in Shengxuening group.In ferrous fumarate group,the adverse reactions occurred in 8 cases,including addominal discomfort,nausea,vomiting,etc.The incidence of adverse reactions was 33.3%.The hsCRP level was significantly increased in ferrous fumarate group(P<0.05).Conclusions Shengxuening can remarkably improve the iron metabolism and assist the treatment of renal anemia of CKD non-dialysis patients without obvious adverse reactions,and does not affect the micro-inflammatory state.The curative effectiveness of Shengxuening is more satisfactfory than that of ferrous fumarate. |
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| ISSN: | 1671-2390 |