The association between high atherogenic index of plasma and impaired lung function: a population-based study
ObjectiveAlthough AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.Met...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1589605/full |
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| author | Liang Yang Yuanzhou Wu Ling Chen Zizhao Li Wenfei Zhu Ziyan Zhang Hui Li Yang Huang Qunqing Chen |
| author_facet | Liang Yang Yuanzhou Wu Ling Chen Zizhao Li Wenfei Zhu Ziyan Zhang Hui Li Yang Huang Qunqing Chen |
| author_sort | Liang Yang |
| collection | DOAJ |
| description | ObjectiveAlthough AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.MethodsData from 4,565 participants in the NHANES 2007–2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV1, FVC, and FEV1/FVC ratio) as outcomes. Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations.ResultsMultivariable regression showed a significant negative association between AIP and FEV1 (β = −121.3 mL/unit, p < 0.001) and FVC (β = −147.1 mL/unit, p < 0.001), with no significant link to FEV1/FVC ratio. Subgroup analysis revealed a U-shaped non-linear association in females, with inflection points at AIP values of 0.77 (FEV1) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels.ConclusionElevated AIP is independently associated with reduced lung function, particularly non-linear effects in females. These findings support AIP as a potential adjunct marker for pulmonary function assessment in clinical practice. |
| format | Article |
| id | doaj-art-e326ca910fa24e6885b79f97a3b0f378 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-e326ca910fa24e6885b79f97a3b0f3782025-08-20T03:28:13ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.15896051589605The association between high atherogenic index of plasma and impaired lung function: a population-based studyLiang YangYuanzhou WuLing ChenZizhao LiWenfei ZhuZiyan ZhangHui LiYang HuangQunqing ChenObjectiveAlthough AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.MethodsData from 4,565 participants in the NHANES 2007–2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV1, FVC, and FEV1/FVC ratio) as outcomes. Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations.ResultsMultivariable regression showed a significant negative association between AIP and FEV1 (β = −121.3 mL/unit, p < 0.001) and FVC (β = −147.1 mL/unit, p < 0.001), with no significant link to FEV1/FVC ratio. Subgroup analysis revealed a U-shaped non-linear association in females, with inflection points at AIP values of 0.77 (FEV1) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels.ConclusionElevated AIP is independently associated with reduced lung function, particularly non-linear effects in females. These findings support AIP as a potential adjunct marker for pulmonary function assessment in clinical practice.https://www.frontiersin.org/articles/10.3389/fmed.2025.1589605/fullatherogenic index of plasmaNHANESlung functioncross-sectional studynon-linear association |
| spellingShingle | Liang Yang Yuanzhou Wu Ling Chen Zizhao Li Wenfei Zhu Ziyan Zhang Hui Li Yang Huang Qunqing Chen The association between high atherogenic index of plasma and impaired lung function: a population-based study Frontiers in Medicine atherogenic index of plasma NHANES lung function cross-sectional study non-linear association |
| title | The association between high atherogenic index of plasma and impaired lung function: a population-based study |
| title_full | The association between high atherogenic index of plasma and impaired lung function: a population-based study |
| title_fullStr | The association between high atherogenic index of plasma and impaired lung function: a population-based study |
| title_full_unstemmed | The association between high atherogenic index of plasma and impaired lung function: a population-based study |
| title_short | The association between high atherogenic index of plasma and impaired lung function: a population-based study |
| title_sort | association between high atherogenic index of plasma and impaired lung function a population based study |
| topic | atherogenic index of plasma NHANES lung function cross-sectional study non-linear association |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1589605/full |
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