Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy
Abstract While the development of nanochemistry has spurred the emergence of catalytic nanomedicine, nanocatalysts with multifaceted catalytic properties for therapeutic applications remain underexplored. Here, we present two-dimensional BiCuSeO nanosheets (BCSO NSs) as the superlattice nanocatalyst...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-61041-4 |
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| author | Shanshan Zhang Xiangyu Kong Ximo Xu Qing Hua Wenwen Xu Liang Chen Jianqiao Zhou Yu Chen |
| author_facet | Shanshan Zhang Xiangyu Kong Ximo Xu Qing Hua Wenwen Xu Liang Chen Jianqiao Zhou Yu Chen |
| author_sort | Shanshan Zhang |
| collection | DOAJ |
| description | Abstract While the development of nanochemistry has spurred the emergence of catalytic nanomedicine, nanocatalysts with multifaceted catalytic properties for therapeutic applications remain underexplored. Here, we present two-dimensional BiCuSeO nanosheets (BCSO NSs) as the superlattice nanocatalyst for multimodal energy transformation-driven nanocatalytic therapy. Benefiting from the intrinsic layered heterostructures and a narrow bandgap, BCSO NSs feature photothermoelectric and sono-piezoelectric catalytic effects, as well as enzyme-mimicking catalytic activities. Theoretical calculations reveal that the internal electric fields within superlattice nanostructures contribute to the rapid separation and suppressed recombination of charge carriers. Consequently, BCSO NSs enable controlled reactive oxygen species generation under the second near-infrared light or ultrasound irradiations. The enzymatic activity of BCSO NSs also facilitates the transformation of tumor-specific substrates, dysregulating the redox homeostasis. The photothermoelectric and sono-piezoelectric/enzymatic activities of BCSO NSs have been exemplified by antibacterial and anticancer applications, highlighting the potential of two-dimensional superlattice nanocatalysts to address diverse pathological abnormalities. |
| format | Article |
| id | doaj-art-e326b4f574f04da68e8833a6a3fa6734 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-e326b4f574f04da68e8833a6a3fa67342025-08-20T03:45:33ZengNature PortfolioNature Communications2041-17232025-07-0116112110.1038/s41467-025-61041-4Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapyShanshan Zhang0Xiangyu Kong1Ximo Xu2Qing Hua3Wenwen Xu4Liang Chen5Jianqiao Zhou6Yu Chen7Department of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of General Surgery, Shanghai General Hospital, Shanghai Jiaotong University School of MedicineDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of MedicineDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of MedicineMaterdicine Lab, School of Life Sciences, Shanghai UniversityDepartment of Ultrasound, Ruijin Hospital, Shanghai Jiaotong University School of MedicineMaterdicine Lab, School of Life Sciences, Shanghai UniversityAbstract While the development of nanochemistry has spurred the emergence of catalytic nanomedicine, nanocatalysts with multifaceted catalytic properties for therapeutic applications remain underexplored. Here, we present two-dimensional BiCuSeO nanosheets (BCSO NSs) as the superlattice nanocatalyst for multimodal energy transformation-driven nanocatalytic therapy. Benefiting from the intrinsic layered heterostructures and a narrow bandgap, BCSO NSs feature photothermoelectric and sono-piezoelectric catalytic effects, as well as enzyme-mimicking catalytic activities. Theoretical calculations reveal that the internal electric fields within superlattice nanostructures contribute to the rapid separation and suppressed recombination of charge carriers. Consequently, BCSO NSs enable controlled reactive oxygen species generation under the second near-infrared light or ultrasound irradiations. The enzymatic activity of BCSO NSs also facilitates the transformation of tumor-specific substrates, dysregulating the redox homeostasis. The photothermoelectric and sono-piezoelectric/enzymatic activities of BCSO NSs have been exemplified by antibacterial and anticancer applications, highlighting the potential of two-dimensional superlattice nanocatalysts to address diverse pathological abnormalities.https://doi.org/10.1038/s41467-025-61041-4 |
| spellingShingle | Shanshan Zhang Xiangyu Kong Ximo Xu Qing Hua Wenwen Xu Liang Chen Jianqiao Zhou Yu Chen Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy Nature Communications |
| title | Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy |
| title_full | Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy |
| title_fullStr | Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy |
| title_full_unstemmed | Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy |
| title_short | Two-dimensional superlattice nanocatalysts unlock multimodal energy transformation-driven catalytic therapy |
| title_sort | two dimensional superlattice nanocatalysts unlock multimodal energy transformation driven catalytic therapy |
| url | https://doi.org/10.1038/s41467-025-61041-4 |
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