ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation

ADCY4 inhibits cAMP-induced growth of breast cancer by inactivating FAK/AKT and ERK signaling but is frequently silenced by DNA methylation

Abstract Local increases in cyclic adenosine monophosphate (cAMP) caused by specific adenylyl cyclases (ACs) can selectively modulate related proteins. AC-selective drugs have an advantage in side effect control, and the specific AC may finally be considered as a therapeutic target. We show that ade...

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Bibliographic Details
Main Authors: Guangrui Pan, Mingquan Huang, Shaozhi Fu, Yu Wang, Lijia He, Bin Wu, Jinping Yang, Sheng Lin, Yu Fan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
ADCY4
Breast cancer
cAMP
DNA methylation
FAK
Online Access:https://doi.org/10.1038/s41598-025-06294-1
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