Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy
A 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosi...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2020/8824974 |
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| author | Tasuku Hara Tomoya Ohara Masashi Taniguchi Toshiaki Sakai Kohei Oka Naoto Iwai Toshifumi Tsuji Takashi Okuda Toshiyuki Komaki Junichi Sakagami Keizo Kagawa |
| author_facet | Tasuku Hara Tomoya Ohara Masashi Taniguchi Toshiaki Sakai Kohei Oka Naoto Iwai Toshifumi Tsuji Takashi Okuda Toshiyuki Komaki Junichi Sakagami Keizo Kagawa |
| author_sort | Tasuku Hara |
| collection | DOAJ |
| description | A 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosis. After achieving SVR, the fibrosis-4 (FIB-4) index level dropped once but gradually increased. 21 years after SVR, hepatocellular carcinoma (HCC) was diagnosed by dynamic computed tomography. The HCC was 12 mm in diameter. The HCC was treated with radiofrequency ablation. CH-C patients with advanced fibrosis require long-term follow-up, even after achieving SVR. |
| format | Article |
| id | doaj-art-e3237f523bf946ee9e3c11932aedb6aa |
| institution | OA Journals |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-e3237f523bf946ee9e3c11932aedb6aa2025-08-20T02:21:24ZengWileyCase Reports in Hepatology2090-65872090-65952020-01-01202010.1155/2020/88249748824974Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon TherapyTasuku Hara0Tomoya Ohara1Masashi Taniguchi2Toshiaki Sakai3Kohei Oka4Naoto Iwai5Toshifumi Tsuji6Takashi Okuda7Toshiyuki Komaki8Junichi Sakagami9Keizo Kagawa10Department of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanDepartment of Gastroenterology and Hepatology, Fukuchiyama City Hospital, Atsunaka-chou 231, Fukuchiyama, Kyoto 620-8505, JapanA 77-year-old man with chronic hepatitis C (CH-C) infection, who achieved a sustained virological response (SVR) to interferon (IFN) therapy, was followed up regularly. Before IFN therapy, he did not have metabolic diseases, and the histological diagnosis of his chronic hepatitis was stage-3 fibrosis. After achieving SVR, the fibrosis-4 (FIB-4) index level dropped once but gradually increased. 21 years after SVR, hepatocellular carcinoma (HCC) was diagnosed by dynamic computed tomography. The HCC was 12 mm in diameter. The HCC was treated with radiofrequency ablation. CH-C patients with advanced fibrosis require long-term follow-up, even after achieving SVR.http://dx.doi.org/10.1155/2020/8824974 |
| spellingShingle | Tasuku Hara Tomoya Ohara Masashi Taniguchi Toshiaki Sakai Kohei Oka Naoto Iwai Toshifumi Tsuji Takashi Okuda Toshiyuki Komaki Junichi Sakagami Keizo Kagawa Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy Case Reports in Hepatology |
| title | Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy |
| title_full | Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy |
| title_fullStr | Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy |
| title_full_unstemmed | Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy |
| title_short | Development of Hepatocellular Carcinoma in a Patient with Chronic Hepatitis C 21 Years after Achieving a Sustained Virological Response to Interferon Therapy |
| title_sort | development of hepatocellular carcinoma in a patient with chronic hepatitis c 21 years after achieving a sustained virological response to interferon therapy |
| url | http://dx.doi.org/10.1155/2020/8824974 |
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