A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF

Abstract Background Amyloid-β42 (Aβ42) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are considered the major neurotoxic agents in Alzheimer’s disease (AD). Cerebral lesions in the brain of AD patients start to develop 20 years before...

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Bibliographic Details
Main Authors: Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Nanobodies
Conformation-sensitive antibodies
Amyloid β peptide
Protein misfolding
Early diagnosis
Biofluids
Online Access:https://doi.org/10.1186/s13195-023-01361-z
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