Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian Carcinoma
Background. Fibrothecomas are benign sex cord-stromal tumors which rarely originate outside of the ovary. To date, two such cases have been reported in the literature. We report the third case of an extraovarian fibrothecoma and the first presenting similarly to a metastatic epithelial ovarian cance...
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| Language: | English |
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Wiley
2012-01-01
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| Series: | Case Reports in Obstetrics and Gynecology |
| Online Access: | http://dx.doi.org/10.1155/2012/281745 |
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| author | Patrick Roberts Sharon Nofech-Mozes Natalie Coburn Paul Hamilton Lilian T. Gien |
| author_facet | Patrick Roberts Sharon Nofech-Mozes Natalie Coburn Paul Hamilton Lilian T. Gien |
| author_sort | Patrick Roberts |
| collection | DOAJ |
| description | Background. Fibrothecomas are benign sex cord-stromal tumors which rarely originate outside of the ovary. To date, two such cases have been reported in the literature. We report the third case of an extraovarian fibrothecoma and the first presenting similarly to a metastatic epithelial ovarian cancer. Clinical History. We describe a 62-year-old woman with history, physical examination, and imaging suggestive of metastatic ovarian cancer. CA-125 was elevated at 1291 U/mL. Paracenteses were negative for malignant cells and core biopsy showed spindle cell proliferation. A primary debulking surgery for a presumed ovarian cancer was planned. Method and Results. At surgery, 6 liters of ascites were drained. The uterus, ovaries, peritoneum, and omentum were normal. An 18×11×7 cm retroperitoneal mass was found between the left ureter and the sigmoid mesocolon, wrapped with sigmoid colon. Fallopian tubes and ovaries were normal. The mass was resected en bloc with the sigmoid colon, uterus, ovaries, and omentum. Microscopically, there was spindle cell proliferation typical of fibrothecoma. No ovarian tissue was identified in association with the tumor. Conclusion. This third case of extraovarian fibrothecoma highlights the importance of obtaining histologic evidence of malignancy prior to initiating neoadjuvant chemotherapy for a presumed ovarian cancer. |
| format | Article |
| id | doaj-art-e31bf63e94e848e5b629fd648435d5e8 |
| institution | Kabale University |
| issn | 2090-6684 2090-6692 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Obstetrics and Gynecology |
| spelling | doaj-art-e31bf63e94e848e5b629fd648435d5e82025-02-03T05:49:57ZengWileyCase Reports in Obstetrics and Gynecology2090-66842090-66922012-01-01201210.1155/2012/281745281745Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian CarcinomaPatrick Roberts0Sharon Nofech-Mozes1Natalie Coburn2Paul Hamilton3Lilian T. Gien4Division of Surgical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, M4N 3M5, CanadaDepartment of Anatomical Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, M4N 3M5, CanadaDivision of Surgical Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, M4N 3M5, CanadaDivision of Radiology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, M4N 3M5, CanadaSunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, ON, M4N 3M5, CanadaBackground. Fibrothecomas are benign sex cord-stromal tumors which rarely originate outside of the ovary. To date, two such cases have been reported in the literature. We report the third case of an extraovarian fibrothecoma and the first presenting similarly to a metastatic epithelial ovarian cancer. Clinical History. We describe a 62-year-old woman with history, physical examination, and imaging suggestive of metastatic ovarian cancer. CA-125 was elevated at 1291 U/mL. Paracenteses were negative for malignant cells and core biopsy showed spindle cell proliferation. A primary debulking surgery for a presumed ovarian cancer was planned. Method and Results. At surgery, 6 liters of ascites were drained. The uterus, ovaries, peritoneum, and omentum were normal. An 18×11×7 cm retroperitoneal mass was found between the left ureter and the sigmoid mesocolon, wrapped with sigmoid colon. Fallopian tubes and ovaries were normal. The mass was resected en bloc with the sigmoid colon, uterus, ovaries, and omentum. Microscopically, there was spindle cell proliferation typical of fibrothecoma. No ovarian tissue was identified in association with the tumor. Conclusion. This third case of extraovarian fibrothecoma highlights the importance of obtaining histologic evidence of malignancy prior to initiating neoadjuvant chemotherapy for a presumed ovarian cancer.http://dx.doi.org/10.1155/2012/281745 |
| spellingShingle | Patrick Roberts Sharon Nofech-Mozes Natalie Coburn Paul Hamilton Lilian T. Gien Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian Carcinoma Case Reports in Obstetrics and Gynecology |
| title | Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian Carcinoma |
| title_full | Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian Carcinoma |
| title_fullStr | Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian Carcinoma |
| title_full_unstemmed | Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian Carcinoma |
| title_short | Retroperitoneal Extraovarian Fibrothecoma Mimicking a Malignant Epithelial Ovarian Carcinoma |
| title_sort | retroperitoneal extraovarian fibrothecoma mimicking a malignant epithelial ovarian carcinoma |
| url | http://dx.doi.org/10.1155/2012/281745 |
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