The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical Trial
A randomized, placebo-controlled, quadruple-blind trial was performed to evaluate the effect of oral administration of the antioxidant combination Spermotrend<sup>®</sup> for three months on semen quality in infertile men with at least one abnormal variable in semen analysis. Eighty men...
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MDPI AG
2025-04-01
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| Series: | Antioxidants |
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| author | Pinelopi Ioannidou Theodosia Zeginiadou Christos Venetis Dimitrios Papanikolaou Leonidas Zepiridis Despoina Savvaidou Katerina Chatzimeletiou Alexandros Lambropoulos Dimitrios G. Goulis Grigoris Grimbizis Efstratios M. Kolibianakis |
| author_facet | Pinelopi Ioannidou Theodosia Zeginiadou Christos Venetis Dimitrios Papanikolaou Leonidas Zepiridis Despoina Savvaidou Katerina Chatzimeletiou Alexandros Lambropoulos Dimitrios G. Goulis Grigoris Grimbizis Efstratios M. Kolibianakis |
| author_sort | Pinelopi Ioannidou |
| collection | DOAJ |
| description | A randomized, placebo-controlled, quadruple-blind trial was performed to evaluate the effect of oral administration of the antioxidant combination Spermotrend<sup>®</sup> for three months on semen quality in infertile men with at least one abnormal variable in semen analysis. Eighty men were randomized between 2019 and 2022, receiving either the antioxidant combination Spermotrend<sup>®</sup> (<i>n</i> = 40, spermotrend-group) or placebo (<i>n</i> = 40, placebo-group). Although a total of 80 patients were enrolled in the study, the final data is only from 70 patients. The primary outcome measure was sperm motility (rapid progressive, progressive, and total motility). The values of primary and secondary outcomes between treatment initiation and treatment completion were compared within groups. Moreover, their changes between treatment initiation and treatment completion were compared between the placebo- and the spermotrend-groups. Sperm rapid progressive motility significantly increased in infertile men treated for three months with antioxidant combination Spermotrend<sup>®</sup> (+1.0%, 95% CI: 0.0 to +2.0, <i>p</i> = 0.04), while this increase was not observed in the placebo-group. Sperm progressive motility significantly increased in infertile men treated for three months with antioxidant combination Spermotrend<sup>®</sup> (+3.0%, 95% CI: 0.0 to +15.1, <i>p</i> = 0.02), while this increase was not observed in the placebo-group. Similarly, DFI was significantly decreased in infertile men treated for three months by antioxidant combination Spermotrend<sup>®</sup> (−3.2%, 95% CI: −5.8 to −0.5, <i>p</i> = 0.02). However, no statistically significant differences were observed in the changes of pre- and post-treatment values between the spermotrend- and the placebo-group regarding sperm progressive motility, concentration, normal morphology, DFI, and formation of 8-OH-dG. The antioxidant combination Spermotrend<sup>®</sup> appears to exert limited benefit on sperm motility and DFI in infertile men with at least one abnormal variable in semen analysis. |
| format | Article |
| id | doaj-art-e31b7e9bbc8f4d79b8b278e3595973a7 |
| institution | OA Journals |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-e31b7e9bbc8f4d79b8b278e3595973a72025-08-20T02:24:43ZengMDPI AGAntioxidants2076-39212025-04-0114448810.3390/antiox14040488The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical TrialPinelopi Ioannidou0Theodosia Zeginiadou1Christos Venetis2Dimitrios Papanikolaou3Leonidas Zepiridis4Despoina Savvaidou5Katerina Chatzimeletiou6Alexandros Lambropoulos7Dimitrios G. Goulis8Grigoris Grimbizis9Efstratios M. Kolibianakis10Unit for Human Reproduction, 1st Department of Obstetrics-Gynecology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceAndrologylab, Andrology Diagnostic Center, 54624 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics-Gynecology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, Greece2nd Department of Urology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 54124 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics-Gynecology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics-Gynecology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics-Gynecology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceLaboratory of Medical Biology—Genetics, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, GreeceUnit of Reproductive Endocrinology, 1st Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 56429 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics-Gynecology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceUnit for Human Reproduction, 1st Department of Obstetrics-Gynecology, School of Medicine, Aristotle University of Thessaloniki, Papageorgiou General Hospital, 56403 Thessaloniki, GreeceA randomized, placebo-controlled, quadruple-blind trial was performed to evaluate the effect of oral administration of the antioxidant combination Spermotrend<sup>®</sup> for three months on semen quality in infertile men with at least one abnormal variable in semen analysis. Eighty men were randomized between 2019 and 2022, receiving either the antioxidant combination Spermotrend<sup>®</sup> (<i>n</i> = 40, spermotrend-group) or placebo (<i>n</i> = 40, placebo-group). Although a total of 80 patients were enrolled in the study, the final data is only from 70 patients. The primary outcome measure was sperm motility (rapid progressive, progressive, and total motility). The values of primary and secondary outcomes between treatment initiation and treatment completion were compared within groups. Moreover, their changes between treatment initiation and treatment completion were compared between the placebo- and the spermotrend-groups. Sperm rapid progressive motility significantly increased in infertile men treated for three months with antioxidant combination Spermotrend<sup>®</sup> (+1.0%, 95% CI: 0.0 to +2.0, <i>p</i> = 0.04), while this increase was not observed in the placebo-group. Sperm progressive motility significantly increased in infertile men treated for three months with antioxidant combination Spermotrend<sup>®</sup> (+3.0%, 95% CI: 0.0 to +15.1, <i>p</i> = 0.02), while this increase was not observed in the placebo-group. Similarly, DFI was significantly decreased in infertile men treated for three months by antioxidant combination Spermotrend<sup>®</sup> (−3.2%, 95% CI: −5.8 to −0.5, <i>p</i> = 0.02). However, no statistically significant differences were observed in the changes of pre- and post-treatment values between the spermotrend- and the placebo-group regarding sperm progressive motility, concentration, normal morphology, DFI, and formation of 8-OH-dG. The antioxidant combination Spermotrend<sup>®</sup> appears to exert limited benefit on sperm motility and DFI in infertile men with at least one abnormal variable in semen analysis.https://www.mdpi.com/2076-3921/14/4/488antioxidantsmale infertilityplaceboSpermotrend<sup>®</sup> |
| spellingShingle | Pinelopi Ioannidou Theodosia Zeginiadou Christos Venetis Dimitrios Papanikolaou Leonidas Zepiridis Despoina Savvaidou Katerina Chatzimeletiou Alexandros Lambropoulos Dimitrios G. Goulis Grigoris Grimbizis Efstratios M. Kolibianakis The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical Trial Antioxidants antioxidants male infertility placebo Spermotrend<sup>®</sup> |
| title | The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical Trial |
| title_full | The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical Trial |
| title_fullStr | The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical Trial |
| title_full_unstemmed | The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical Trial |
| title_short | The Effect of Antioxidant Administration on Semen Quality in Men with Infertility: A Randomized Placebo-Controlled Clinical Trial |
| title_sort | effect of antioxidant administration on semen quality in men with infertility a randomized placebo controlled clinical trial |
| topic | antioxidants male infertility placebo Spermotrend<sup>®</sup> |
| url | https://www.mdpi.com/2076-3921/14/4/488 |
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