The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients
Background Endothelial dysfunction was shown to contribute significantly to the elevated cardiovascular risk observed in the general population. However, the relationship between endothelial dysfunction and subclinical myocardial injury in obstructive sleep apnoea (OSA) patients remains unclear. Met...
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2025-02-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/11/1/00691-2024.full |
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| author | Wenhao Cao Jinmei Luo Xinjie Hui Yi Xiao Rong Huang |
| author_facet | Wenhao Cao Jinmei Luo Xinjie Hui Yi Xiao Rong Huang |
| author_sort | Wenhao Cao |
| collection | DOAJ |
| description | Background
Endothelial dysfunction was shown to contribute significantly to the elevated cardiovascular risk observed in the general population. However, the relationship between endothelial dysfunction and subclinical myocardial injury in obstructive sleep apnoea (OSA) patients remains unclear.
Methods
This cross-sectional study recruited 165 consecutive male patients diagnosed with OSA. All participants underwent overnight polysomnography to confirm the diagnosis and assess the severity of OSA. Subclinical myocardial injury was evaluated using high-sensitivity cardiac troponin I (hs-cTnI) measurements, while endothelial dysfunction was assessed through the peripheral arterial tonometry.
Results
Endothelial dysfunction was present in 80 (48.5%) of the subjects and hs-cTnI was detectable in 147 (89.1%) of the participants. When compared with OSA patients without endothelial dysfunction, those with endothelial dysfunction exhibited significantly lower percentages of hypertension (23.8% versus 43.5%, p=0.007) and abdominal obesity (76.3% versus 88.2%, p=0.043). Patients with endothelial dysfunction frequently manifest a lower apnoea–hypopnoea index and oxygen desaturation index. Despite comparable median hs-cTnI levels, a higher proportion of subjects with detectable hs-cTnI levels was observed among those with endothelial dysfunction (95% versus 83.5%, p=0.018). Logistic regression analysis indicated that endothelial dysfunction was significantly associated with a detectable level of hs-cTnI after adjustment for multiple confounders.
Conclusions
In male OSA patients, endothelial dysfunction appears to be potentially correlated with an increased risk of subclinical myocardial injury, as evidenced by the higher prevalence of detectable hs-cTnI levels. Further investigations are warranted to elucidate the role of endothelial dysfunction in predicting future cardiovascular mortality in this population. |
| format | Article |
| id | doaj-art-e31b7e1d2ea349bcb4b4438e352aaec9 |
| institution | DOAJ |
| issn | 2312-0541 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj-art-e31b7e1d2ea349bcb4b4438e352aaec92025-08-20T03:16:36ZengEuropean Respiratory SocietyERJ Open Research2312-05412025-02-0111110.1183/23120541.00691-202400691-2024The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patientsWenhao Cao0Jinmei Luo1Xinjie Hui2Yi Xiao3Rong Huang4 Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Background Endothelial dysfunction was shown to contribute significantly to the elevated cardiovascular risk observed in the general population. However, the relationship between endothelial dysfunction and subclinical myocardial injury in obstructive sleep apnoea (OSA) patients remains unclear. Methods This cross-sectional study recruited 165 consecutive male patients diagnosed with OSA. All participants underwent overnight polysomnography to confirm the diagnosis and assess the severity of OSA. Subclinical myocardial injury was evaluated using high-sensitivity cardiac troponin I (hs-cTnI) measurements, while endothelial dysfunction was assessed through the peripheral arterial tonometry. Results Endothelial dysfunction was present in 80 (48.5%) of the subjects and hs-cTnI was detectable in 147 (89.1%) of the participants. When compared with OSA patients without endothelial dysfunction, those with endothelial dysfunction exhibited significantly lower percentages of hypertension (23.8% versus 43.5%, p=0.007) and abdominal obesity (76.3% versus 88.2%, p=0.043). Patients with endothelial dysfunction frequently manifest a lower apnoea–hypopnoea index and oxygen desaturation index. Despite comparable median hs-cTnI levels, a higher proportion of subjects with detectable hs-cTnI levels was observed among those with endothelial dysfunction (95% versus 83.5%, p=0.018). Logistic regression analysis indicated that endothelial dysfunction was significantly associated with a detectable level of hs-cTnI after adjustment for multiple confounders. Conclusions In male OSA patients, endothelial dysfunction appears to be potentially correlated with an increased risk of subclinical myocardial injury, as evidenced by the higher prevalence of detectable hs-cTnI levels. Further investigations are warranted to elucidate the role of endothelial dysfunction in predicting future cardiovascular mortality in this population.http://openres.ersjournals.com/content/11/1/00691-2024.full |
| spellingShingle | Wenhao Cao Jinmei Luo Xinjie Hui Yi Xiao Rong Huang The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients ERJ Open Research |
| title | The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients |
| title_full | The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients |
| title_fullStr | The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients |
| title_full_unstemmed | The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients |
| title_short | The association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients |
| title_sort | association between endothelial dysfunction and subclinical myocardial injury in male obstructive sleep apnoea patients |
| url | http://openres.ersjournals.com/content/11/1/00691-2024.full |
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