Successful long-term survival following lipiodol chemoembolization for hepatocellular carcinoma in Alagille syndrome: A case report

Successful long-term survival following lipiodol chemoembolization for hepatocellular carcinoma in Alagille syndrome: A case report

Alagille syndrome is a rare genetic disorder causing multisystem complications, including biliary abnormalities, chronic liver disease, and rarely, hepatocellular carcinoma (HCC), which is difficult to manage due to liver dysfunction and vascular abnormalities. We report a 29-year-old female, diagno...

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Main Authors: Imad Akasbi, MD, Ismail Chaouche, MD, Nizar El Bouardi, MD, Amal Akammar, MD, Hajar O Chahdi, MD, Ismail Zerrari, MD, Maria Lahlali, MD, Hakima Abid, MD, Badr Alami, MD, Nada Lahmidani, MD, Meryem Boubbou, MD, Ibrahimi Sidi adil, MD, Mustapha Maaroufi, MD, MY Youssef Alaoui Lamrani, MD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Radiology Case Reports
Subjects:
HCC
Lipiodol chemoembolization
Alagille syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S1930043325004236
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Summary:Alagille syndrome is a rare genetic disorder causing multisystem complications, including biliary abnormalities, chronic liver disease, and rarely, hepatocellular carcinoma (HCC), which is difficult to manage due to liver dysfunction and vascular abnormalities. We report a 29-year-old female, diagnosed with Alagille syndrome in infancy, who developed infiltrative HCC at age 20 and underwent lipiodol-based transarterial chemoembolization (TACE) in 2015, with a second session in 2016 for recurrence. Remarkably, she has achieved an exceptional 9-year survival post-treatment with stable imaging and no recurrence, a highly uncommon outcome for HCC in Alagille syndrome, highlighting TACE’s potential as an effective palliative treatment for HCC in Alagille syndrome, particularly for patient's ineligible for liver transplantation, and underscoring the need for further studies on locoregional therapies in this rare population.
ISSN:1930-0433

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