Decoding disease–specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validationResearch in context

Decoding disease–specific ageing mechanisms through pathway-level epigenetic clock: insights from multi-cohort validationResearch in context

Summary: Background: Ageing is a multifactorial process closely associated with increased risk of chronic diseases. While epigenetic clocks have advanced ageing research, most rely on isolated CpG sites, limiting biological interpretability. We developed PathwayAge, a biologically informed model th...

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Main Authors: Pan Li, Jijun Zhu, Shenghan Wang, Haowen Zhuang, Shunjie Zhang, Zhongting Huang, Fuqiang Cai, Zhijian Song, Yuxin Liu, Weixin Liu, Sebastian Freidel, Sijia Wang, Emanuel Schwarz, Junfang Chen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:EBioMedicine
Subjects:
Epigenetic clock
DNA methylation
Pathway-level analysis
Machine learning
Disease association
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002737
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