Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases
Metabolic reprogramming is the process by which cells adapt to different patterns of energy metabolism in response to the demands of the microenvironment for energy and biological macromolecules. Glucose serves as the primary energy source for cellular survival, and its metabolic pathways are intric...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1551452/full |
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| author | Zhen Li Shuo-Xuan Chen Shuai Jiang Yi-Nong Yang Xi-Chan Yan |
| author_facet | Zhen Li Shuo-Xuan Chen Shuai Jiang Yi-Nong Yang Xi-Chan Yan |
| author_sort | Zhen Li |
| collection | DOAJ |
| description | Metabolic reprogramming is the process by which cells adapt to different patterns of energy metabolism in response to the demands of the microenvironment for energy and biological macromolecules. Glucose serves as the primary energy source for cellular survival, and its metabolic pathways are intricately associated with cellular functional states. Recent studies have demonstrated that alterations in glucose metabolism, along with non-metabolic functions of metabolic enzymes and metabolites, play crucial roles in the development and progression of lung diseases under inflammatory conditions. This review summarizes the regulatory mechanisms of glucose metabolism across various pulmonary disorders and discusses the non-metabolic functions of glycolytic enzymes and metabolites in relation to disease pathogenesis. We aim to shine new light on the diagnosis and treatment of lung disease. |
| format | Article |
| id | doaj-art-e30dc0ed3da04a98895aba661356921d |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-e30dc0ed3da04a98895aba661356921d2025-08-20T03:37:33ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-08-011610.3389/fphar.2025.15514521551452Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseasesZhen Li0Shuo-Xuan Chen1Shuai Jiang2Yi-Nong Yang3Xi-Chan Yan4School of Basic Medical Sciences, Hunan University of Medicine, Huaihua, Hunan, ChinaSchool of Rehabilitation Medicine and Health, Hunan University of Medicine, Huaihua, Hunan, ChinaSchool of Basic Medical Sciences, Hunan University of Medicine, Huaihua, Hunan, ChinaSchool of Basic Medical Sciences, Hunan University of Medicine, Huaihua, Hunan, ChinaQiandongnan People’s Hospital, Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou, ChinaMetabolic reprogramming is the process by which cells adapt to different patterns of energy metabolism in response to the demands of the microenvironment for energy and biological macromolecules. Glucose serves as the primary energy source for cellular survival, and its metabolic pathways are intricately associated with cellular functional states. Recent studies have demonstrated that alterations in glucose metabolism, along with non-metabolic functions of metabolic enzymes and metabolites, play crucial roles in the development and progression of lung diseases under inflammatory conditions. This review summarizes the regulatory mechanisms of glucose metabolism across various pulmonary disorders and discusses the non-metabolic functions of glycolytic enzymes and metabolites in relation to disease pathogenesis. We aim to shine new light on the diagnosis and treatment of lung disease.https://www.frontiersin.org/articles/10.3389/fphar.2025.1551452/fullglucose metabolism reprogrammingpneumoniaacute respiratory distress syndromechronic obstructive pulmonary diseaselung cancerpulmonary fibrosis |
| spellingShingle | Zhen Li Shuo-Xuan Chen Shuai Jiang Yi-Nong Yang Xi-Chan Yan Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases Frontiers in Pharmacology glucose metabolism reprogramming pneumonia acute respiratory distress syndrome chronic obstructive pulmonary disease lung cancer pulmonary fibrosis |
| title | Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases |
| title_full | Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases |
| title_fullStr | Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases |
| title_full_unstemmed | Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases |
| title_short | Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases |
| title_sort | unlocking the secrets of glucose metabolism reprogramming the role in pulmonary diseases |
| topic | glucose metabolism reprogramming pneumonia acute respiratory distress syndrome chronic obstructive pulmonary disease lung cancer pulmonary fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1551452/full |
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