The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell Lymphoma
Diffuse Large B-cell Lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma (NHL). Despite the use of newer agents, such as polatuzumab vedotin, more than one-third of patients have ultimately relapsed or experienced refractory disease. MiRNAs are single-stranded, ~22-nucleotide-long RN...
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MDPI AG
2024-11-01
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| author | Epameinondas Koumpis Vasileios Georgoulis Konstantina Papathanasiou Alexandra Papoudou-Bai Panagiotis Kanavaros Evangelos Kolettas Eleftheria Hatzimichael |
| author_facet | Epameinondas Koumpis Vasileios Georgoulis Konstantina Papathanasiou Alexandra Papoudou-Bai Panagiotis Kanavaros Evangelos Kolettas Eleftheria Hatzimichael |
| author_sort | Epameinondas Koumpis |
| collection | DOAJ |
| description | Diffuse Large B-cell Lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma (NHL). Despite the use of newer agents, such as polatuzumab vedotin, more than one-third of patients have ultimately relapsed or experienced refractory disease. MiRNAs are single-stranded, ~22-nucleotide-long RNAs that interact with their target RNA. They are significant regulators of post-transcriptional gene expression. One significant miRNA, miR-155, is involved in the pathophysiology of DLBCL and it is a critical modulator of hematopoiesis, inflammation, and immune responses. Targets of miR-155, such as histone deacetylase 4 (HDAC4), suppressor of cytokine signaling-1 (SOCS1) and immune cells, play a crucial role in DLBCL pathogenesis, since miR-155 regulates key pathways, transcription factors and cytokine expression and shapes the tumor microenvironment in DLBCL. In this review, we examine the role of miR-155 in DLBCL and its potential as a future diagnostic, prognostic, or predictive biomarker. |
| format | Article |
| id | doaj-art-e30c2d02b1f64e9ca7ef6de791c73852 |
| institution | DOAJ |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-e30c2d02b1f64e9ca7ef6de791c738522025-08-20T02:50:52ZengMDPI AGBiomedicines2227-90592024-11-011212265810.3390/biomedicines12122658The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell LymphomaEpameinondas Koumpis0Vasileios Georgoulis1Konstantina Papathanasiou2Alexandra Papoudou-Bai3Panagiotis Kanavaros4Evangelos Kolettas5Eleftheria Hatzimichael6Department of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Pathology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDepartment of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, GreeceLaboratory of Biology, Faculty of Medicine, School of Health Sciences, Institute of Biosciences, University Centre for Research and Innovation, University of Ioannina, 45110 Ioannina, GreeceDepartment of Hematology, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45500 Ioannina, GreeceDiffuse Large B-cell Lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma (NHL). Despite the use of newer agents, such as polatuzumab vedotin, more than one-third of patients have ultimately relapsed or experienced refractory disease. MiRNAs are single-stranded, ~22-nucleotide-long RNAs that interact with their target RNA. They are significant regulators of post-transcriptional gene expression. One significant miRNA, miR-155, is involved in the pathophysiology of DLBCL and it is a critical modulator of hematopoiesis, inflammation, and immune responses. Targets of miR-155, such as histone deacetylase 4 (HDAC4), suppressor of cytokine signaling-1 (SOCS1) and immune cells, play a crucial role in DLBCL pathogenesis, since miR-155 regulates key pathways, transcription factors and cytokine expression and shapes the tumor microenvironment in DLBCL. In this review, we examine the role of miR-155 in DLBCL and its potential as a future diagnostic, prognostic, or predictive biomarker.https://www.mdpi.com/2227-9059/12/12/2658lymphomaDLBCLmiRNAsmiR-155biomarkerslymphomagenesis |
| spellingShingle | Epameinondas Koumpis Vasileios Georgoulis Konstantina Papathanasiou Alexandra Papoudou-Bai Panagiotis Kanavaros Evangelos Kolettas Eleftheria Hatzimichael The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell Lymphoma Biomedicines lymphoma DLBCL miRNAs miR-155 biomarkers lymphomagenesis |
| title | The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell Lymphoma |
| title_full | The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell Lymphoma |
| title_fullStr | The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell Lymphoma |
| title_full_unstemmed | The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell Lymphoma |
| title_short | The Role of microRNA-155 as a Biomarker in Diffuse Large B-Cell Lymphoma |
| title_sort | role of microrna 155 as a biomarker in diffuse large b cell lymphoma |
| topic | lymphoma DLBCL miRNAs miR-155 biomarkers lymphomagenesis |
| url | https://www.mdpi.com/2227-9059/12/12/2658 |
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