A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population
Abstract This study investigated the associations between CAV1 variants and metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiometabolic risk factors, as well as the influence of CAV1 variants on CAV1 mRNA expression. We genotyped 743 T2DM patients for CAV1 variants. Multiple logi...
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Nature Portfolio
2024-11-01
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| Online Access: | https://doi.org/10.1038/s41598-024-78534-9 |
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| author | Metha Yaikwawong Pornpimon Ek-eudomsuk Gunya Sittithumcharee Vipavee Anupunpisit Thavatchai Peerapatdit Chaicharn Deerochanawong Thep Himathongkam Siwanon Jirawatnotai Somlak Chuengsamarn |
| author_facet | Metha Yaikwawong Pornpimon Ek-eudomsuk Gunya Sittithumcharee Vipavee Anupunpisit Thavatchai Peerapatdit Chaicharn Deerochanawong Thep Himathongkam Siwanon Jirawatnotai Somlak Chuengsamarn |
| author_sort | Metha Yaikwawong |
| collection | DOAJ |
| description | Abstract This study investigated the associations between CAV1 variants and metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiometabolic risk factors, as well as the influence of CAV1 variants on CAV1 mRNA expression. We genotyped 743 T2DM patients for CAV1 variants. Multiple logistic regression was conducted to adjust for sex, age, and body mass index (BMI), and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The expression of mRNA was measured by reverse transcription polymerase chain reaction. The rs926198 variant, but not the rs3807989 variant, was associated with T2DM. Crude ORs were 1.87 (95% CI: 1.32–2.69, p = 0.0005) and adjusted ORs were 1.81 (95% CI: 1.12–2.96, p = 0.016), respectively. Additionally, patients with Mets and T2DM who had the rs926198 variant exhibited a significant 44.3% reduction in CAV1 mRNA expression (P < 0.05). Clinical samples revealed that the rs926198 variant is strongly linked to T2DM, with significantly reduced CAV1 mRNA. Our findings suggest a crucial role for the rs926198 variant in T2DM, indicating its potential for prevention, diagnosis, and intervention purposes. |
| format | Article |
| id | doaj-art-e30bceb4596c400b832c52c680c691c0 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e30bceb4596c400b832c52c680c691c02025-02-09T12:38:05ZengNature PortfolioScientific Reports2045-23222024-11-011411910.1038/s41598-024-78534-9A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai populationMetha Yaikwawong0Pornpimon Ek-eudomsuk1Gunya Sittithumcharee2Vipavee Anupunpisit3Thavatchai Peerapatdit4Chaicharn Deerochanawong5Thep Himathongkam6Siwanon Jirawatnotai7Somlak Chuengsamarn8Department of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol UniversitySiriraj Center of Research for Excellence, Siriraj Center of Research for Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol UniversitySiriraj Center of Research for Excellence, Siriraj Center of Research for Excellence for Systems Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol UniversityDepartment of Anatomy, Faculty of Medicine, Srinakharinwirot UniversityDivision of Endocrinology and Metabolism, Faculty of Medicine, Siriraj Hospital, Mahidol UniversityDivision of Endocrinology and Metabolism, Department of Medicine, Rajavithi HospitalTheptarin Diabetes Center and HospitalDepartment of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol UniversityDivision of Endocrinology and Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot UniversityAbstract This study investigated the associations between CAV1 variants and metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiometabolic risk factors, as well as the influence of CAV1 variants on CAV1 mRNA expression. We genotyped 743 T2DM patients for CAV1 variants. Multiple logistic regression was conducted to adjust for sex, age, and body mass index (BMI), and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. The expression of mRNA was measured by reverse transcription polymerase chain reaction. The rs926198 variant, but not the rs3807989 variant, was associated with T2DM. Crude ORs were 1.87 (95% CI: 1.32–2.69, p = 0.0005) and adjusted ORs were 1.81 (95% CI: 1.12–2.96, p = 0.016), respectively. Additionally, patients with Mets and T2DM who had the rs926198 variant exhibited a significant 44.3% reduction in CAV1 mRNA expression (P < 0.05). Clinical samples revealed that the rs926198 variant is strongly linked to T2DM, with significantly reduced CAV1 mRNA. Our findings suggest a crucial role for the rs926198 variant in T2DM, indicating its potential for prevention, diagnosis, and intervention purposes.https://doi.org/10.1038/s41598-024-78534-9Cardiometabolic risk factorsCAV1 geneInsulin resistanceMetabolic syndromers926198 variantType 2 diabetes mellitus |
| spellingShingle | Metha Yaikwawong Pornpimon Ek-eudomsuk Gunya Sittithumcharee Vipavee Anupunpisit Thavatchai Peerapatdit Chaicharn Deerochanawong Thep Himathongkam Siwanon Jirawatnotai Somlak Chuengsamarn A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population Scientific Reports Cardiometabolic risk factors CAV1 gene Insulin resistance Metabolic syndrome rs926198 variant Type 2 diabetes mellitus |
| title | A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population |
| title_full | A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population |
| title_fullStr | A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population |
| title_full_unstemmed | A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population |
| title_short | A prevalent caveolin-1 gene rs926198 variant is associated with type 2 diabetes mellitus in the Thai population |
| title_sort | prevalent caveolin 1 gene rs926198 variant is associated with type 2 diabetes mellitus in the thai population |
| topic | Cardiometabolic risk factors CAV1 gene Insulin resistance Metabolic syndrome rs926198 variant Type 2 diabetes mellitus |
| url | https://doi.org/10.1038/s41598-024-78534-9 |
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