Advancements in the investigation of radioactive microspheres for brachytherapy
In clinical practice, the management of most non-surgically resectable solid tumors necessitates a multidisciplinary treatment approach. Optimal solutions involve the integration of local and systemic treatments, such as targeted immunotherapy and chemotherapy. Micron-sized radioactive microspheres...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1621418/full |
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| author | Xiaohui Jiang Xiaohui Jiang Lei Chen Lei Chen Xiao Xu Xiao Xu |
| author_facet | Xiaohui Jiang Xiaohui Jiang Lei Chen Lei Chen Xiao Xu Xiao Xu |
| author_sort | Xiaohui Jiang |
| collection | DOAJ |
| description | In clinical practice, the management of most non-surgically resectable solid tumors necessitates a multidisciplinary treatment approach. Optimal solutions involve the integration of local and systemic treatments, such as targeted immunotherapy and chemotherapy. Micron-sized radioactive microspheres or particles have gained widespread application in the localized treatment of various organ tumors, encompassing liver cancer, lung cancer, tongue cancer, pancreatic cancer, head and neck cancer, ovarian cancer, bone cancer, among others. As such, the design and development of novel multifunctional radioactive microspheres constitute a crucial foundation for achieving effective local treatment in liver cancer and other cancer types. This article critically reviews the current developmental landscape, identifies challenges, and explores opportunities in the field of radioactive internal irradiation microspheres in recent years. The insights provided serve as a valuable reference for selecting and determining the developmental direction of clinical brachytherapy treatment carriers. |
| format | Article |
| id | doaj-art-e309c3dafa554cba88a1cb008e25bd9d |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-e309c3dafa554cba88a1cb008e25bd9d2025-08-20T03:27:43ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-07-011310.3389/fbioe.2025.16214181621418Advancements in the investigation of radioactive microspheres for brachytherapyXiaohui Jiang0Xiaohui Jiang1Lei Chen2Lei Chen3Xiao Xu4Xiao Xu5Cancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, ChinaGuangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, ChinaCancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, ChinaGuangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, ChinaCancer Center, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, The 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, ChinaGuangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, The 10th Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, ChinaIn clinical practice, the management of most non-surgically resectable solid tumors necessitates a multidisciplinary treatment approach. Optimal solutions involve the integration of local and systemic treatments, such as targeted immunotherapy and chemotherapy. Micron-sized radioactive microspheres or particles have gained widespread application in the localized treatment of various organ tumors, encompassing liver cancer, lung cancer, tongue cancer, pancreatic cancer, head and neck cancer, ovarian cancer, bone cancer, among others. As such, the design and development of novel multifunctional radioactive microspheres constitute a crucial foundation for achieving effective local treatment in liver cancer and other cancer types. This article critically reviews the current developmental landscape, identifies challenges, and explores opportunities in the field of radioactive internal irradiation microspheres in recent years. The insights provided serve as a valuable reference for selecting and determining the developmental direction of clinical brachytherapy treatment carriers.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1621418/fulltumorradiationbrachytherapyradioactive microspherestheranostics |
| spellingShingle | Xiaohui Jiang Xiaohui Jiang Lei Chen Lei Chen Xiao Xu Xiao Xu Advancements in the investigation of radioactive microspheres for brachytherapy Frontiers in Bioengineering and Biotechnology tumor radiation brachytherapy radioactive microspheres theranostics |
| title | Advancements in the investigation of radioactive microspheres for brachytherapy |
| title_full | Advancements in the investigation of radioactive microspheres for brachytherapy |
| title_fullStr | Advancements in the investigation of radioactive microspheres for brachytherapy |
| title_full_unstemmed | Advancements in the investigation of radioactive microspheres for brachytherapy |
| title_short | Advancements in the investigation of radioactive microspheres for brachytherapy |
| title_sort | advancements in the investigation of radioactive microspheres for brachytherapy |
| topic | tumor radiation brachytherapy radioactive microspheres theranostics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1621418/full |
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