Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload
Diuretics, including furosemide, metolazone, and spironolactone, have historically been the mainstay of therapy for acute decompensated heart failure patients. The addition of an aquaretic-like vasopressin antagonist may enhance diuresis further. However, clinical experience with this quadruple comb...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Cardiology |
| Online Access: | http://dx.doi.org/10.1155/2013/750794 |
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| author | Rita Jermyn Naveed Rajper Chelsea Estrada Sagar Patel Michelle Weisfelner Bloom Nand K. Wadhwa |
| author_facet | Rita Jermyn Naveed Rajper Chelsea Estrada Sagar Patel Michelle Weisfelner Bloom Nand K. Wadhwa |
| author_sort | Rita Jermyn |
| collection | DOAJ |
| description | Diuretics, including furosemide, metolazone, and spironolactone, have historically been the mainstay of therapy for acute decompensated heart failure patients. The addition of an aquaretic-like vasopressin antagonist may enhance diuresis further. However, clinical experience with this quadruple combination is lacking in the acute setting. We present two hospitalized patients with acute decompensated heart failure due to massive fluid overload treated with a combination strategy of triple diuretics in conjunction with the aquaretic tolvaptan. The first patient lost 72.1 lbs. (32.7 kg) with an average urine output of 3.5 to 7.5 L/day over eight days on combined therapy with furosemide, metolazone, spironolactone, and tolvaptan. The second patient similarly achieved a weight loss of 28.2 lbs. (12.8 kg) over 4 days on the same treatment. Both patients maintained stable serum sodium, potassium, and creatinine over this period and remained out of the hospital for more than 30 days. Thus, patients hospitalized with acute decompensated heart failure due to volume overload can achieve euvolemia rapidly and without electrolytes disturbances using this regimen, while being under the close supervision of a team of cardiologists and nephrologists. Additionally, this therapy can potentially decrease the need for ultrafiltration and the length of hospital stay. |
| format | Article |
| id | doaj-art-e30938c10ab94ad4995fc4532633ca39 |
| institution | OA Journals |
| issn | 2090-6404 2090-6412 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Cardiology |
| spelling | doaj-art-e30938c10ab94ad4995fc4532633ca392025-08-20T02:21:14ZengWileyCase Reports in Cardiology2090-64042090-64122013-01-01201310.1155/2013/750794750794Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume OverloadRita Jermyn0Naveed Rajper1Chelsea Estrada2Sagar Patel3Michelle Weisfelner Bloom4Nand K. Wadhwa5Division of Cardiology, Department of Medicine, Stony Brook Medicine, Stony Brook, NY 11794, USADepartment of Medicine, Stony Brook Medicine, Stony Brook, NY 11794, USADivision of Nephrology, Department of Medicine, Stony Brook Medicine, Stony Brook, NY 11794, USADivision of Nephrology, Department of Medicine, Stony Brook Medicine, Stony Brook, NY 11794, USADivision of Cardiology, Department of Medicine, Stony Brook Medicine, Stony Brook, NY 11794, USADivision of Nephrology, Department of Medicine, Stony Brook Medicine, Stony Brook, NY 11794, USADiuretics, including furosemide, metolazone, and spironolactone, have historically been the mainstay of therapy for acute decompensated heart failure patients. The addition of an aquaretic-like vasopressin antagonist may enhance diuresis further. However, clinical experience with this quadruple combination is lacking in the acute setting. We present two hospitalized patients with acute decompensated heart failure due to massive fluid overload treated with a combination strategy of triple diuretics in conjunction with the aquaretic tolvaptan. The first patient lost 72.1 lbs. (32.7 kg) with an average urine output of 3.5 to 7.5 L/day over eight days on combined therapy with furosemide, metolazone, spironolactone, and tolvaptan. The second patient similarly achieved a weight loss of 28.2 lbs. (12.8 kg) over 4 days on the same treatment. Both patients maintained stable serum sodium, potassium, and creatinine over this period and remained out of the hospital for more than 30 days. Thus, patients hospitalized with acute decompensated heart failure due to volume overload can achieve euvolemia rapidly and without electrolytes disturbances using this regimen, while being under the close supervision of a team of cardiologists and nephrologists. Additionally, this therapy can potentially decrease the need for ultrafiltration and the length of hospital stay.http://dx.doi.org/10.1155/2013/750794 |
| spellingShingle | Rita Jermyn Naveed Rajper Chelsea Estrada Sagar Patel Michelle Weisfelner Bloom Nand K. Wadhwa Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload Case Reports in Cardiology |
| title | Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload |
| title_full | Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload |
| title_fullStr | Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload |
| title_full_unstemmed | Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload |
| title_short | Triple Diuretics and Aquaretic Strategy for Acute Decompensated Heart Failure due to Volume Overload |
| title_sort | triple diuretics and aquaretic strategy for acute decompensated heart failure due to volume overload |
| url | http://dx.doi.org/10.1155/2013/750794 |
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