Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern
Background: Cribriform comedo-type adenocarcinoma (CCA) was a colon cancer subtype defined in the 2009 World Health Organization (WHO) classification. In the 2018 classification, it was a colon cancer subtype included in the adenocarcinoma, Not otherwise specified (NOS) group. A few studies have rep...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_194_23 |
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| author | Tuğba Günler Pinar Karabağli Hicret Tiyek Özge Keskin Muslu K. Körez |
| author_facet | Tuğba Günler Pinar Karabağli Hicret Tiyek Özge Keskin Muslu K. Körez |
| author_sort | Tuğba Günler |
| collection | DOAJ |
| description | Background:
Cribriform comedo-type adenocarcinoma (CCA) was a colon cancer subtype defined in the 2009 World Health Organization (WHO) classification. In the 2018 classification, it was a colon cancer subtype included in the adenocarcinoma, Not otherwise specified (NOS) group. A few studies have reported that colon cancers with a cribriform pattern have worse overall survival, and most of them are microsatellite stable (MSS). In this study, we evaluated CCAs based on their clinicopathologic features and microsatellite stability. We aimed to answer whether these tumors could be defined as a distinct morphologic subtype with prognostic significance.
Materials and Methods:
Pathology reports and specimens from 449 patients with colorectal adenocarcinoma (CRA) were re-evaluated. All subtypes were determined. To evaluate MSS status, the CCA cases were immunohistochemically stained with anti-MLH1, MSH2, MSH6, and PMS2 antibodies.
Results:
CCA was present in 40.5% of cases. These cases were found to have higher rates of lymph node metastasis, lymphovascular-perineural invasion, metastasis, and advanced stage (P < 0.05). Also, 2.7% of CCA cases were microsatellite instable (MSI). However, no statistically significant result was found regarding overall survival and progression-free survival of CCA cases with MSI.
Conclusion:
According to the findings, CRAs with comedo cribriform patterns are tumors with more aggressive features. It can be said that these tumors have a specific molecular feature related to MSS. Because this feature is important for planning adjuvant chemotherapy, it may be useful to identify cases, particularly with a cribriform comedo pattern >90%. However, because no significant difference in survival rates was found, CCAs may not need to be defined as distinct subtypes. |
| format | Article |
| id | doaj-art-e305f8e6f44b43c3b38749803c6a52ff |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-e305f8e6f44b43c3b38749803c6a52ff2025-02-07T13:56:01ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-04-0167227528110.4103/ijpm.ijpm_194_23Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo patternTuğba GünlerPinar KarabağliHicret TiyekÖzge KeskinMuslu K. KörezBackground: Cribriform comedo-type adenocarcinoma (CCA) was a colon cancer subtype defined in the 2009 World Health Organization (WHO) classification. In the 2018 classification, it was a colon cancer subtype included in the adenocarcinoma, Not otherwise specified (NOS) group. A few studies have reported that colon cancers with a cribriform pattern have worse overall survival, and most of them are microsatellite stable (MSS). In this study, we evaluated CCAs based on their clinicopathologic features and microsatellite stability. We aimed to answer whether these tumors could be defined as a distinct morphologic subtype with prognostic significance. Materials and Methods: Pathology reports and specimens from 449 patients with colorectal adenocarcinoma (CRA) were re-evaluated. All subtypes were determined. To evaluate MSS status, the CCA cases were immunohistochemically stained with anti-MLH1, MSH2, MSH6, and PMS2 antibodies. Results: CCA was present in 40.5% of cases. These cases were found to have higher rates of lymph node metastasis, lymphovascular-perineural invasion, metastasis, and advanced stage (P < 0.05). Also, 2.7% of CCA cases were microsatellite instable (MSI). However, no statistically significant result was found regarding overall survival and progression-free survival of CCA cases with MSI. Conclusion: According to the findings, CRAs with comedo cribriform patterns are tumors with more aggressive features. It can be said that these tumors have a specific molecular feature related to MSS. Because this feature is important for planning adjuvant chemotherapy, it may be useful to identify cases, particularly with a cribriform comedo pattern >90%. However, because no significant difference in survival rates was found, CCAs may not need to be defined as distinct subtypes.https://journals.lww.com/10.4103/ijpm.ijpm_194_23colorectal carcinomacomedocribriformmicrosatellite stabilityprognosis |
| spellingShingle | Tuğba Günler Pinar Karabağli Hicret Tiyek Özge Keskin Muslu K. Körez Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern Indian Journal of Pathology and Microbiology colorectal carcinoma comedo cribriform microsatellite stability prognosis |
| title | Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern |
| title_full | Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern |
| title_fullStr | Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern |
| title_full_unstemmed | Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern |
| title_short | Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern |
| title_sort | clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern |
| topic | colorectal carcinoma comedo cribriform microsatellite stability prognosis |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_194_23 |
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