Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastases
Abstract Oxidative stress has been implicated as a pivotal factor in the pathogenesis of numerous malignancies. However, the association between oxidative stress and the prognosis of patients with colorectal cancer liver metastasis (CRCLM) is not well elucidated. We conducted a retrospective analysi...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86693-6 |
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| author | Wei Li Liming Shen Qinglin Yang Qun Zhang Yinghao Cao Tao Liu |
| author_facet | Wei Li Liming Shen Qinglin Yang Qun Zhang Yinghao Cao Tao Liu |
| author_sort | Wei Li |
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| description | Abstract Oxidative stress has been implicated as a pivotal factor in the pathogenesis of numerous malignancies. However, the association between oxidative stress and the prognosis of patients with colorectal cancer liver metastasis (CRCLM) is not well elucidated. We conducted a retrospective analysis of 424 patients with CRCLM who underwent primary resection at the Union Hospital, Tongji Medical College, Wuhan, between July 2013 and September 2018. Patients were randomly divided into a training set (n = 300) and a test set (n = 124) in a 7:3 ratio.To develop the CRCLM-integrated Oxidative Stress Score (CLIOSS) for CRCLM, we utilized individual oxidative stress markers. The overall survival (OS) and disease-free survival (DFS) were estimated using the Kaplan-Meier method, and the log-rank test was employed to assess prognostic factors.To validate the predictive performance of CLIOSS, we constructed Receiver Operating Characteristic (ROC) curves and calculated the Area Under the Curve (AUC) values. Additionally, Decision Curve Analysis (DCA) and calibration plots were used to evaluate the clinical utility and predictive consistency of the model. The CLIOSS prognostic model was constructed based on the following variables and their corresponding β coefficients: 0.042 × total bilirubin (TBIL, µmol/L) + 0.032 × blood urea nitrogen (BUN, mmol/L) − 0.001 × uric acid (UA, µmol/L). Higher CLIOSS were associated with poorer OS (2.934;95% CI 2.167–3.974;P < 0.001) and DFS(2.707; 95% CI 2.000–3.664; P < 0.001. The 3-year OS AUC values were 0.803 in the training set and 0.851 in the testset, while the 3-year DFS AUC values were 0.892 and 0.898, respectively. Decision curve analysis demonstrated that both predictive models have significant clinical utility in practice. CLIOSS is a comprehensive prognostic index derived from oxidative stress markers, designed to predict long-term survival in patients with CRCLM. Our study shows that higher CLIOSS are significantly associated with poorer outcomes, making it an important tool for assessing patient risk. |
| format | Article |
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| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-e305f26fec9444888ddfc1c29d5b00852025-08-20T03:09:35ZengNature PortfolioScientific Reports2045-23222025-02-0115111710.1038/s41598-025-86693-6Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastasesWei Li0Liming Shen1Qinglin Yang2Qun Zhang3Yinghao Cao4Tao Liu5Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Oxidative stress has been implicated as a pivotal factor in the pathogenesis of numerous malignancies. However, the association between oxidative stress and the prognosis of patients with colorectal cancer liver metastasis (CRCLM) is not well elucidated. We conducted a retrospective analysis of 424 patients with CRCLM who underwent primary resection at the Union Hospital, Tongji Medical College, Wuhan, between July 2013 and September 2018. Patients were randomly divided into a training set (n = 300) and a test set (n = 124) in a 7:3 ratio.To develop the CRCLM-integrated Oxidative Stress Score (CLIOSS) for CRCLM, we utilized individual oxidative stress markers. The overall survival (OS) and disease-free survival (DFS) were estimated using the Kaplan-Meier method, and the log-rank test was employed to assess prognostic factors.To validate the predictive performance of CLIOSS, we constructed Receiver Operating Characteristic (ROC) curves and calculated the Area Under the Curve (AUC) values. Additionally, Decision Curve Analysis (DCA) and calibration plots were used to evaluate the clinical utility and predictive consistency of the model. The CLIOSS prognostic model was constructed based on the following variables and their corresponding β coefficients: 0.042 × total bilirubin (TBIL, µmol/L) + 0.032 × blood urea nitrogen (BUN, mmol/L) − 0.001 × uric acid (UA, µmol/L). Higher CLIOSS were associated with poorer OS (2.934;95% CI 2.167–3.974;P < 0.001) and DFS(2.707; 95% CI 2.000–3.664; P < 0.001. The 3-year OS AUC values were 0.803 in the training set and 0.851 in the testset, while the 3-year DFS AUC values were 0.892 and 0.898, respectively. Decision curve analysis demonstrated that both predictive models have significant clinical utility in practice. CLIOSS is a comprehensive prognostic index derived from oxidative stress markers, designed to predict long-term survival in patients with CRCLM. Our study shows that higher CLIOSS are significantly associated with poorer outcomes, making it an important tool for assessing patient risk.https://doi.org/10.1038/s41598-025-86693-6Colorectal Cancer Liver MetastasisCRCLM-Integrated oxidative stress scorePrognosisSurvival Nomogram |
| spellingShingle | Wei Li Liming Shen Qinglin Yang Qun Zhang Yinghao Cao Tao Liu Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastases Scientific Reports Colorectal Cancer Liver Metastasis CRCLM-Integrated oxidative stress score Prognosis Survival Nomogram |
| title | Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastases |
| title_full | Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastases |
| title_fullStr | Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastases |
| title_full_unstemmed | Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastases |
| title_short | Oxidative stress index-based scoring for prediction of long-term prognosis in patients with colorectal cancer with liver metastases |
| title_sort | oxidative stress index based scoring for prediction of long term prognosis in patients with colorectal cancer with liver metastases |
| topic | Colorectal Cancer Liver Metastasis CRCLM-Integrated oxidative stress score Prognosis Survival Nomogram |
| url | https://doi.org/10.1038/s41598-025-86693-6 |
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