Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study)
Abstract Background Colorectal cancer (CRC) is a prevalent and lethal malignancy. This study examines differences in clinical and prognostic characteristics of CRC between patients under 50 years and those aged 50 and above, treated at a reference hospital in Southern Brazil. Methods A retrospective...
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2025-02-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03607-6 |
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| author | Otavio de Carvalho Modaffar Al-Alam Rafael Jose Vargas Alves Adele Lanziani Fae Camile Neves Cardoso Jamille Rizzardi Lava Joanna Palmeira Castro Julia Signori Larissa Grazziotin Claudino Tales Barros Cassal Wandscheer Victor Viecceli Villarinho Affoue Prisca Michelle S. Yao Claudia Giuliano Bica |
| author_facet | Otavio de Carvalho Modaffar Al-Alam Rafael Jose Vargas Alves Adele Lanziani Fae Camile Neves Cardoso Jamille Rizzardi Lava Joanna Palmeira Castro Julia Signori Larissa Grazziotin Claudino Tales Barros Cassal Wandscheer Victor Viecceli Villarinho Affoue Prisca Michelle S. Yao Claudia Giuliano Bica |
| author_sort | Otavio de Carvalho Modaffar Al-Alam |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) is a prevalent and lethal malignancy. This study examines differences in clinical and prognostic characteristics of CRC between patients under 50 years and those aged 50 and above, treated at a reference hospital in Southern Brazil. Methods A retrospective cohort study was conducted, analyzing data from the Cancer Hospital Registry in Porto Alegre, RS. Patients diagnosed with colon or rectal adenocarcinoma between January 2013 and December 2017 were included. Variables analyzed included family history, alcoholism, smoking status, clinical staging, tumor laterality, clinical presentation, CEA levels at diagnosis, adjuvant chemotherapy, and neutrophil-to-lymphocyte ratio. Results The study cohort included 1,121 patients, with 85% aged 50 years or older, and 15% younger than 50 years. Significant differences were observed in smoking status and clinical presentation, with younger patients presenting with a higher prevalence of obstruction/subocclusion at diagnosis, which may reflect differences in clinical presentation due to delayed diagnosis. Conclusions Age and lifestyle factors, particularly smoking, significantly influenced the clinical presentation and management of colorectal cancer. These findings underscore the importance of targeted prevention strategies and personalized treatment approaches for younger CRC patients. |
| format | Article |
| id | doaj-art-e305164280064e0a9ba47b8c82aed78b |
| institution | OA Journals |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj-art-e305164280064e0a9ba47b8c82aed78b2025-08-20T02:15:11ZengBMCBMC Gastroenterology1471-230X2025-02-012511710.1186/s12876-025-03607-6Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study)Otavio de Carvalho Modaffar Al-Alam0Rafael Jose Vargas Alves1Adele Lanziani Fae2Camile Neves Cardoso3Jamille Rizzardi Lava4Joanna Palmeira Castro5Julia Signori6Larissa Grazziotin Claudino7Tales Barros Cassal Wandscheer8Victor Viecceli Villarinho9Affoue Prisca Michelle S. Yao10Claudia Giuliano Bica11Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre (UFCSPA)Department of Internal Medicine, Federal University of Health Sciences of Porto Alegre (UFCSPA)Undergraduate Medicine Program, Lutheran University of Brazil (ULBRA)Undergraduate Medicine Program, Lutheran University of Brazil (ULBRA)Clinical Oncology Department, Hospital Santa Rita, Santa Casa HospitalUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA)Clinical Oncology Department, Hospital Santa Rita, Santa Casa HospitalUndergraduate Medicine Program, Lutheran University of Brazil (ULBRA)Undergraduate Medicine Program, Lutheran University of Brazil (ULBRA)Undergraduate Medicine Program, Lutheran University of Brazil (ULBRA)Undergraduate Medicine Program, Federal University of Rio Grande do Sul (UFRGS)Graduate Program in Pathology, Federal University of Health Sciences of Porto Alegre (UFCSPA)Abstract Background Colorectal cancer (CRC) is a prevalent and lethal malignancy. This study examines differences in clinical and prognostic characteristics of CRC between patients under 50 years and those aged 50 and above, treated at a reference hospital in Southern Brazil. Methods A retrospective cohort study was conducted, analyzing data from the Cancer Hospital Registry in Porto Alegre, RS. Patients diagnosed with colon or rectal adenocarcinoma between January 2013 and December 2017 were included. Variables analyzed included family history, alcoholism, smoking status, clinical staging, tumor laterality, clinical presentation, CEA levels at diagnosis, adjuvant chemotherapy, and neutrophil-to-lymphocyte ratio. Results The study cohort included 1,121 patients, with 85% aged 50 years or older, and 15% younger than 50 years. Significant differences were observed in smoking status and clinical presentation, with younger patients presenting with a higher prevalence of obstruction/subocclusion at diagnosis, which may reflect differences in clinical presentation due to delayed diagnosis. Conclusions Age and lifestyle factors, particularly smoking, significantly influenced the clinical presentation and management of colorectal cancer. These findings underscore the importance of targeted prevention strategies and personalized treatment approaches for younger CRC patients.https://doi.org/10.1186/s12876-025-03607-6Colorectal cancerEpidemiologyClinical characteristicsAge differencesRetrospective cohort studySouthern Brazil |
| spellingShingle | Otavio de Carvalho Modaffar Al-Alam Rafael Jose Vargas Alves Adele Lanziani Fae Camile Neves Cardoso Jamille Rizzardi Lava Joanna Palmeira Castro Julia Signori Larissa Grazziotin Claudino Tales Barros Cassal Wandscheer Victor Viecceli Villarinho Affoue Prisca Michelle S. Yao Claudia Giuliano Bica Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study) BMC Gastroenterology Colorectal cancer Epidemiology Clinical characteristics Age differences Retrospective cohort study Southern Brazil |
| title | Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study) |
| title_full | Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study) |
| title_fullStr | Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study) |
| title_full_unstemmed | Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study) |
| title_short | Clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in Southern Brazil: comparative study based on age (Retrospective cohort study) |
| title_sort | clinical and demographic analysis of patients with colorectal cancer screened at a reference hospital in southern brazil comparative study based on age retrospective cohort study |
| topic | Colorectal cancer Epidemiology Clinical characteristics Age differences Retrospective cohort study Southern Brazil |
| url | https://doi.org/10.1186/s12876-025-03607-6 |
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