Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids

Triggering AHR resolves TGF-β1 induced fibroblast activation and promotes AT1 cell regeneration in alveolar organoids

Abstract Regeneration of the alveolar epithelium is necessary to restore tissue architecture and gas exchange capabilities in chronic pulmonary diseases such as fibrosing interstitial lung disease. While it is known alveolar type 2 (AT2) cells give rise to alveolar type 1 (AT1) cells to repair the a...

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Main Authors: Andrew S. Hagan, Scott Williams, Casey J. N. Mathison, Shanshan Yan, Bao Nguyen, Glenn C. Federe, Guray Kuzu, Joseph C. Siefert, Janice Hampton, Victor Chichkov, S. Whitney Barnes, Frederick J. King, Brandon L. Taylor, John R. Walker, Rui Zhao, Jimmy Elliott, Dean P. Phillips, Bin Fang, Rebekah S. Decker
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08446-5
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