Unbiased phage display screening identifies hidden malaria vaccine targets
Malaria is among the deadliest infectious diseases. Over 200 million annual clinical malaria cases are reported and more than half a million people, mostly children, die every year. The most advanced RTS,S/AS01 vaccine based on the P. falciparum circumsporozoite protein (CSP), targets sporozoite liv...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2024.2429617 |
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| author | Marcelo Jacobs-Lorena Sung-Jae Cha |
| author_facet | Marcelo Jacobs-Lorena Sung-Jae Cha |
| author_sort | Marcelo Jacobs-Lorena |
| collection | DOAJ |
| description | Malaria is among the deadliest infectious diseases. Over 200 million annual clinical malaria cases are reported and more than half a million people, mostly children, die every year. The most advanced RTS,S/AS01 vaccine based on the P. falciparum circumsporozoite protein (CSP), targets sporozoite liver infection but achieved modest efficacy. To reduce malaria death, novel malaria vaccine development is a high priority. Most malaria vaccine candidates target three infection steps: sporozoite liver infection, merozoite red blood cell (RBC) infection, and mosquito midgut infection. However, only few malaria vaccine candidates target specific parasite–host cell interactions. Our group has implemented the phage peptide-display approach to discover new parasite ligands and host cell receptors. Here we summarize our findings and discuss their potential for the development of novel vaccines. |
| format | Article |
| id | doaj-art-e30304767ca24b1eb265a1f99fc7412a |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-e30304767ca24b1eb265a1f99fc7412a2025-08-20T02:37:32ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512024-12-0113110.1080/22221751.2024.2429617Unbiased phage display screening identifies hidden malaria vaccine targetsMarcelo Jacobs-Lorena0Sung-Jae Cha1Department of Molecular Microbiology and Immunology and Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USADepartment of Medical Sciences, Mercer University School of Medicine, Macon, GA, USAMalaria is among the deadliest infectious diseases. Over 200 million annual clinical malaria cases are reported and more than half a million people, mostly children, die every year. The most advanced RTS,S/AS01 vaccine based on the P. falciparum circumsporozoite protein (CSP), targets sporozoite liver infection but achieved modest efficacy. To reduce malaria death, novel malaria vaccine development is a high priority. Most malaria vaccine candidates target three infection steps: sporozoite liver infection, merozoite red blood cell (RBC) infection, and mosquito midgut infection. However, only few malaria vaccine candidates target specific parasite–host cell interactions. Our group has implemented the phage peptide-display approach to discover new parasite ligands and host cell receptors. Here we summarize our findings and discuss their potential for the development of novel vaccines.https://www.tandfonline.com/doi/10.1080/22221751.2024.2429617Malariaparasite ligandhost cell receptorphage displayvaccine target |
| spellingShingle | Marcelo Jacobs-Lorena Sung-Jae Cha Unbiased phage display screening identifies hidden malaria vaccine targets Emerging Microbes and Infections Malaria parasite ligand host cell receptor phage display vaccine target |
| title | Unbiased phage display screening identifies hidden malaria vaccine targets |
| title_full | Unbiased phage display screening identifies hidden malaria vaccine targets |
| title_fullStr | Unbiased phage display screening identifies hidden malaria vaccine targets |
| title_full_unstemmed | Unbiased phage display screening identifies hidden malaria vaccine targets |
| title_short | Unbiased phage display screening identifies hidden malaria vaccine targets |
| title_sort | unbiased phage display screening identifies hidden malaria vaccine targets |
| topic | Malaria parasite ligand host cell receptor phage display vaccine target |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2024.2429617 |
| work_keys_str_mv | AT marcelojacobslorena unbiasedphagedisplayscreeningidentifieshiddenmalariavaccinetargets AT sungjaecha unbiasedphagedisplayscreeningidentifieshiddenmalariavaccinetargets |