Effect of methotrexate/dexamethasone combination on epithelial-mesenchymal transition and inflammation gene expression of human RPE cells in-vitro

Effect of methotrexate/dexamethasone combination on epithelial-mesenchymal transition and inflammation gene expression of human RPE cells in-vitro

IntroductionRPE cells serve as an experimental model for studying a retinal disease called proliferative vitreoretinopathy (PVR). The pathological background of PVR involves uncontrolled cell proliferation, increased inflammation, and enhanced epithelial-mesenchymal transition (EMT), which have been...

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Bibliographic Details
Main Authors: Fatemeh Sanie-Jahromi, Mahdi Ravankhah, Hossein Shafi Khani, Seyed Ahmad Razavizadegan, M. Hossein Nowroozzadeh
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
methotrexate
dexamethasone
apoptosis
inflammation
EMT
RPE
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1569703/full
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