The role of ferroptosis-related non-coding RNA in liver fibrosis
Liver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte damage. It delineates the initial stage in the progression of chronic liver disease. This pathological progression is characterized by the excessive accumulation of the extracel...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1517401/full |
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| author | Guozhu Zhang Kejia Wu Kejia Wu Xiaobo Jiang Yuan Gao Dong Ding Hao Wang Chongyuan Yu Xiaozhong Wang Naixin Jia Li Zhu |
| author_facet | Guozhu Zhang Kejia Wu Kejia Wu Xiaobo Jiang Yuan Gao Dong Ding Hao Wang Chongyuan Yu Xiaozhong Wang Naixin Jia Li Zhu |
| author_sort | Guozhu Zhang |
| collection | DOAJ |
| description | Liver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte damage. It delineates the initial stage in the progression of chronic liver disease. This pathological progression is characterized by the excessive accumulation of the extracellular matrix (ECM), which leads to significant structural disruption and ultimately impairs liver function. To date, no specific antifibrotic drugs have been developed, and advanced liver fibrosis remains largely incurable. Liver transplantation remains the sole efficacious intervention for advanced liver fibrosis; nevertheless, it is constrained by exorbitant costs and the risk of postoperative immune rejection, underscoring the imperative for novel therapeutic strategies. Ferroptosis, an emergent form of regulated cell death, has been identified as a pivotal regulatory mechanism in the development of liver fibrosis and is intricately linked with the progression of liver diseases. Recent investigations have elucidated that a diverse array of non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are involved in the ferroptosis pathway, thereby modulating the progression of various diseases, including liver fibrosis. In recent years, the roles of ferroptosis and ferroptosis-related ncRNAs in liver fibrosis have attracted escalating scholarly attention. This paper elucidates the pathophysiology of liver fibrosis, explores the mechanisms underlying ferroptosis, and delineates the involvement of ncRNA-mediated ferroptosis pathways in the pathology of liver fibrosis. It aims to propose novel strategies for the prevention and therapeutic intervention of liver fibrosis. |
| format | Article |
| id | doaj-art-e3018208085343baa1d4201d2d23efc0 |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-e3018208085343baa1d4201d2d23efc02025-08-20T02:30:41ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-12-011210.3389/fcell.2024.15174011517401The role of ferroptosis-related non-coding RNA in liver fibrosisGuozhu Zhang0Kejia Wu1Kejia Wu2Xiaobo Jiang3Yuan Gao4Dong Ding5Hao Wang6Chongyuan Yu7Xiaozhong Wang8Naixin Jia9Li Zhu10Department of Emergency Medicine, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, ChinaKunshan Zhenchuan Community Health Service Center, Kunshan, Jiangsu, ChinaDepartment of Hepato-Biliary-Pancreatic Surgery, The Institute of Hepatobiliary and Pancreatic Diseases, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Hepato-Biliary-Pancreatic Surgery, The Institute of Hepatobiliary and Pancreatic Diseases, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, ChinaDepartment of Emergency Medicine, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaDepartment of General Surgery, Wujin Affiliated Hospital of Jiangsu University and the Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, ChinaDepartment of Hepatobiliary Surgery, Kunshan First People’s Hospital affiliated to Jiangsu University, Kunshan, Jiangsu, ChinaDepartment of Emergency Medicine, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, ChinaLiver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte damage. It delineates the initial stage in the progression of chronic liver disease. This pathological progression is characterized by the excessive accumulation of the extracellular matrix (ECM), which leads to significant structural disruption and ultimately impairs liver function. To date, no specific antifibrotic drugs have been developed, and advanced liver fibrosis remains largely incurable. Liver transplantation remains the sole efficacious intervention for advanced liver fibrosis; nevertheless, it is constrained by exorbitant costs and the risk of postoperative immune rejection, underscoring the imperative for novel therapeutic strategies. Ferroptosis, an emergent form of regulated cell death, has been identified as a pivotal regulatory mechanism in the development of liver fibrosis and is intricately linked with the progression of liver diseases. Recent investigations have elucidated that a diverse array of non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are involved in the ferroptosis pathway, thereby modulating the progression of various diseases, including liver fibrosis. In recent years, the roles of ferroptosis and ferroptosis-related ncRNAs in liver fibrosis have attracted escalating scholarly attention. This paper elucidates the pathophysiology of liver fibrosis, explores the mechanisms underlying ferroptosis, and delineates the involvement of ncRNA-mediated ferroptosis pathways in the pathology of liver fibrosis. It aims to propose novel strategies for the prevention and therapeutic intervention of liver fibrosis.https://www.frontiersin.org/articles/10.3389/fcell.2024.1517401/fullliver fibrosisferroptosismiRNAlncRNAcircRNA |
| spellingShingle | Guozhu Zhang Kejia Wu Kejia Wu Xiaobo Jiang Yuan Gao Dong Ding Hao Wang Chongyuan Yu Xiaozhong Wang Naixin Jia Li Zhu The role of ferroptosis-related non-coding RNA in liver fibrosis Frontiers in Cell and Developmental Biology liver fibrosis ferroptosis miRNA lncRNA circRNA |
| title | The role of ferroptosis-related non-coding RNA in liver fibrosis |
| title_full | The role of ferroptosis-related non-coding RNA in liver fibrosis |
| title_fullStr | The role of ferroptosis-related non-coding RNA in liver fibrosis |
| title_full_unstemmed | The role of ferroptosis-related non-coding RNA in liver fibrosis |
| title_short | The role of ferroptosis-related non-coding RNA in liver fibrosis |
| title_sort | role of ferroptosis related non coding rna in liver fibrosis |
| topic | liver fibrosis ferroptosis miRNA lncRNA circRNA |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1517401/full |
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