Synthesis of Unsymmetrical Urea Derivatives via PhI(OAc)<sub>2</sub> and Application in Late-Stage Drug Functionalization

Synthesis of Unsymmetrical Urea Derivatives via PhI(OAc)<sub>2</sub> and Application in Late-Stage Drug Functionalization

Unsymmetrical urea derivatives are essential structural motifs in a wide array of biologically significant compounds. Despite the well-established methods for synthesizing symmetrical ureas, efficient strategies for the synthesis of unsymmetrical urea derivatives remain limited. In this study, we pr...

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Bibliographic Details
Main Authors: Subban Kathiravan, Prakriti Dhillon, Tianshu Zhang, Ian A. Nicholls
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
hypervalent iodine
urea
amides
amines
late-stage functionalization
drugs
Online Access:https://www.mdpi.com/1420-3049/29/23/5669
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