Corneal Ulcer Following Prolonged Topical Chloroquine Phosphate
Chloroquine and hydroxychloroquine are well known weapons in a rheumatologist's armamentarium. Chloroquine, (N'-(7-chloroquinolin-4-yl)-N, N-diethyl-pentane-1,4-diamine) is an antimalarial drug which has been in use since the early 1950s, in the treatment of Discoid and Systemic Lupus Eryt...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-04-01
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| Series: | Delhi Journal of Ophthalmology |
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| Online Access: | https://journals.lww.com/10.7869/djo.355 |
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| author | Samarth Mishra Sudeep Das |
| author_facet | Samarth Mishra Sudeep Das |
| author_sort | Samarth Mishra |
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| description | Chloroquine and hydroxychloroquine are well known weapons in a rheumatologist's armamentarium. Chloroquine, (N'-(7-chloroquinolin-4-yl)-N, N-diethyl-pentane-1,4-diamine) is an antimalarial drug which has been in use since the early 1950s, in the treatment of Discoid and Systemic Lupus Erythematoses, Rheumatoid Arthritis and dermal light sensitivity eruptions. Hobbs in 1959 recognised a retinopathy which was produced by the long-term administration of this drug. Since the proposal of its anti-inflammatory effect, chloroquine phosphate has been used for the treatment of dry eyes. Among the many side-effects following systemic use of chloroquine; pruritus, urticaria, alopecia, lymphedema of forearm, headache, nausea etc are noteworthy. Ophthalmological complications like bull's eye maculopathy, keratopathy, corneal deposits have also been observed, although infrequently. Majority of the complications arise from the long-term use of the drug which leads to its accumulation in specific sites. Here, we present a rare case report of sterile corneal ulcer following prolonged use of preservative free topical chloroquine phosphate (0.03%w/v) in the form of unims. |
| format | Article |
| id | doaj-art-e3008aba62974f59aefc8c63c8d3766e |
| institution | Kabale University |
| issn | 0972-0200 2454-2784 |
| language | English |
| publishDate | 2018-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Delhi Journal of Ophthalmology |
| spelling | doaj-art-e3008aba62974f59aefc8c63c8d3766e2025-08-20T03:52:28ZengWolters Kluwer Medknow PublicationsDelhi Journal of Ophthalmology0972-02002454-27842018-04-01284424310.7869/djo.355Corneal Ulcer Following Prolonged Topical Chloroquine PhosphateSamarth MishraSudeep DasChloroquine and hydroxychloroquine are well known weapons in a rheumatologist's armamentarium. Chloroquine, (N'-(7-chloroquinolin-4-yl)-N, N-diethyl-pentane-1,4-diamine) is an antimalarial drug which has been in use since the early 1950s, in the treatment of Discoid and Systemic Lupus Erythematoses, Rheumatoid Arthritis and dermal light sensitivity eruptions. Hobbs in 1959 recognised a retinopathy which was produced by the long-term administration of this drug. Since the proposal of its anti-inflammatory effect, chloroquine phosphate has been used for the treatment of dry eyes. Among the many side-effects following systemic use of chloroquine; pruritus, urticaria, alopecia, lymphedema of forearm, headache, nausea etc are noteworthy. Ophthalmological complications like bull's eye maculopathy, keratopathy, corneal deposits have also been observed, although infrequently. Majority of the complications arise from the long-term use of the drug which leads to its accumulation in specific sites. Here, we present a rare case report of sterile corneal ulcer following prolonged use of preservative free topical chloroquine phosphate (0.03%w/v) in the form of unims.https://journals.lww.com/10.7869/djo.355chloroquine toxicitycorneal ulcerchloroquine eye dropschloroquine phosphate |
| spellingShingle | Samarth Mishra Sudeep Das Corneal Ulcer Following Prolonged Topical Chloroquine Phosphate Delhi Journal of Ophthalmology chloroquine toxicity corneal ulcer chloroquine eye drops chloroquine phosphate |
| title | Corneal Ulcer Following Prolonged Topical Chloroquine Phosphate |
| title_full | Corneal Ulcer Following Prolonged Topical Chloroquine Phosphate |
| title_fullStr | Corneal Ulcer Following Prolonged Topical Chloroquine Phosphate |
| title_full_unstemmed | Corneal Ulcer Following Prolonged Topical Chloroquine Phosphate |
| title_short | Corneal Ulcer Following Prolonged Topical Chloroquine Phosphate |
| title_sort | corneal ulcer following prolonged topical chloroquine phosphate |
| topic | chloroquine toxicity corneal ulcer chloroquine eye drops chloroquine phosphate |
| url | https://journals.lww.com/10.7869/djo.355 |
| work_keys_str_mv | AT samarthmishra cornealulcerfollowingprolongedtopicalchloroquinephosphate AT sudeepdas cornealulcerfollowingprolongedtopicalchloroquinephosphate |